SENP8 matures the NEDD8 proenzyme into the active form and regulates NEDDylation by removing NEDD8 from over‐NEDDylated proteins. In this work, SENP8 inhibitor candidates were identified in two rounds of virtual high‐throughput screening. Of the ten candidates identified in the first round of ...
NEDDylation阻断剂的医药用途(19)中华人民共和国国家知识产权局 (12)发明专利申请 (10)申请公布号 CN111265520A(43)申请公布日 2020.06.12 (21)申请号CN201811482037.7 (22)申请日2018.12.05 (71)申请人上海中医药大学附属龙华医院;华东理工大学 地址200032 上海市徐汇区宛平南路725号 (72)发明人贾立军;李剑;...
结论:Neddylation修饰与lamin B1表达呈正相关,靶向neddylation修饰可能通过P53依赖的方式抑制lamin B1的表达。这为乳腺癌的治疗提供了新的靶点和方向。 [关键词]:类泛素化;Neddylation;Lamin B1;乳腺癌 [Abstract]Background and purpose:The...
摘要：Neddylation 修饰是近年来发现的新型蛋白质翻译后修饰，可以广泛地调节生物学过程，如细胞周期、信号传导和免疫识别等。Neddylation 修饰在多种肿瘤细胞中过度活化并促进肿瘤的发生、发展，如阻断此修饰通路具有显著的抗肿瘤效果。Neddylation 修饰的小分子抑制剂MLN4924可使肿瘤细胞发生细胞周期阻滞、衰老和凋亡，同时...
Deregulated Neddylation in Liver Fibrosis Hepatic fibrosis is a global health problem currently without effective therapeutic approaches. Even though the ubiquitin‐like posttranslational modification of neddylation, that conjugates Nedd8 (neural precursor cell expressed develop... I Zubiete-Franco,P ...
Neddylation inhibition upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma Zhou, Shaolong,Zhao,etc.Neddylation inhibition upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma[J].2019,... S Zhou,X Zhao,Z ...
SENP8 matures the NEDD8 proenzyme into the active form and regulates NEDDylation by removing NEDD8 from over‐NEDDylated proteins. In this work, SENP8 inhibitor candidates were identified in two rounds of virtual high‐throughput screening. Of the ten candidates identified in the first round of ...
Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents 来自 NCBI 喜欢 0 阅读量: 42 作者:C Paiva,JC Godbersen,A Berger,JR Brown,AV Danilov 摘要: Microenvironment-mediated upregulation of the B-cell receptor (BCR) ...
Deregulated neddylation in liver fibrosis. Hepatic fibrosis is a global health problem currently without effective therapeutic approaches. Even though the ubiquitin-like posttranslational modificati... Imanol,Zubiete-Franco,Pablo,... - 《Hepatology》...