[68Ga]-N188是一种双环肽基nectin-4靶向抗体放射性示踪剂,能够高亲和力,特异性靶向人体Nectin 4受体,已经获得国家发明专利(授权号 CN114133434B)。 临床研究简介 该研究利用Total-body PET/CT对2名健康志愿者和14名转移性膀胱癌患者进...
2、nectins属于免疫球蛋白超家族并且是骨髓灰质炎病毒受体(pvr/cd155)的同源物,为此,也称为骨髓灰质炎病毒受体结合蛋白(prr)。迄今为止,已描述了5名成员pvr/cd155、nectin-1/prr1/cd111、nectin-2/prr2/cd112、nectin-3/prr3和nectin-4/prr4(1,10-13)。它们的胞外域由三个免疫球蛋白样(ig)v、c、c型...
Recruitment of Nectin-3 to Cell-Cell Junctions through trans-Heterophilic Interaction with CD155, a Vitronectin and Poliovirus Receptor That Localizes to ... Nectins present a novel class of Ig superfamily adhesion molecules that, cooperatively with cadherins, establish and maintain cell-cell adheren...
并将nectin-4基因的阅读框通过酶切的方法克隆入含有谷氨酰氨合成酶(gs)筛选基因的稳定表达载体中,电转染(nucleofector iib,lonza)悬浮培养的cho-k1细胞,将转染后的细胞置于含有50μm msx(sigma,cat:m5379)的cd cho agttm 培养基(gibco,cat:12490-025)中,接种于96孔细胞培养板,37℃,5%co2...