[6] Deng, H., Shi,H., Chen, L. et al. Over-expression of Nectin-4 promotes progression ofesophageal cancer and correlates with poor prognosis of the patients. CancerCell Int 19, 106 (2019).[7] Zhang J,Liu RJ, et al. 9MW2821, a nectin-4 antibody-drug conjugate (ADC), in patie...
[2]Expression of nectin-4 in prostate cancer. North Clin Istanb. 2023 Sep 25;10(5):583-588. doi: 10.14744/nci.2023.36034. PMID: 37829757; PMCID: PMC10565758. [3]Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment. Cancers (Basel). 20...
由于Nectin-4高表达会促进肿瘤多种进化机制,如细胞增殖分化、血管生成、淋巴管生成及淋巴转移,所以在癌症的发生和转移中功不可没,具备一定的预测效果,而且Nectin-4高表达的癌症患者往往也有着不良的预后。在肺癌中[4],Nectin-4表达的上调对肺癌细胞的生长和侵袭起着重要作用,Nectin-4阳性患者的中位生存时间较Nectin-...
由于Nectin-4高表达会促进肿瘤多种进化机制,如细胞增殖分化、血管生成、淋巴管生成及淋巴转移,所以在癌症的发生和转移中功不可没,具备一定的预测效果,而且Nectin-4高表达的癌症患者往往也有着不良的预后。在肺癌中[4],Nectin-4表达的上调对肺癌细胞的生长和侵袭起着重要作用,Nectin-4阳性患者的中位生存时间较Nectin-...
[6] Deng, H., Shi,H., Chen, L. et al. Over-expression of Nectin-4 promotes progression ofesophageal cancer and correlates with poor prognosis of the patients. CancerCell Int 19, 106 (2019). [7] Zhang J,Liu RJ, et al. 9MW2821, a nectin-4 antibody-drug conjugate (ADC), in pat...
[5] Deng, H., Shi, H., Chen, L. et al. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int 19, 106 (2019). [6] Liu R, Zh...
Deng H, Shi H, Chen L, Zhou Y, Jiang J. Over-expression of nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int. 2019;19:106. doi:10.1186/s12935-019-0824-z Lin X, Hu...
However, there were no significant correlations of tumor Nectin-4 expression with tumor-infiltrating T cells. Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer....
Nectin 4蛋白高表达与高浆性卵巢癌患者生存期缩短相关,尤其见于腹膜粟粒状播散型肿瘤。 高Nectin 4肿瘤显示免疫相关基因(如HLA I类)表达降低,可能削弱抗肿瘤免疫反应。 染色体22q11/12区域基因表达减少,6q21区域基因缺失与Nectin 4高表达相关,提示特定基因异常驱动肿瘤进展。
Nectin-4在人类成年人的正常组织中通常表达较低,但在各种癌细胞上表达较高。 正常的人体组织显示出ectin-4的弱到中度的免疫组化表达,包括胎盘、皮肤、唾液腺、食道和胃等。 The RNA (a) and protein (b) expression profiles of Nectin-4 in normal human tissues. ...