OBJECTIVE: Nectin-4 is a transmembrane protein belonging to the nectin family of immunoglobulin-like molecules which is found in the placenta and trachea under physiological conditions and its expression has been shown in many cancer types. We aimed to investigate for the 1st time nectin-4 ...
et al. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int 19, 106 (2019). [6] Liu R, Zhao K, Wang K, Zhang L, Ma W, Qiu Z, Wang W. Prognostic value of nectin-4 in human cancers: A meta-...
[5] Deng, H., Shi, H., Chen, L. et al. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int 19, 106 (2019). [6] Liu R, Zh...
[6] Deng, H., Shi,H., Chen, L. et al. Over-expression of Nectin-4 promotes progression ofesophageal cancer and correlates with poor prognosis of the patients. CancerCell Int 19, 106 (2019).[7] Zhang J,Liu RJ, et al. 9MW2821, a nectin-4 antibody-drug conjugate (ADC), in patie...
[2]Expression of nectin-4 in prostate cancer. North Clin Istanb. 2023 Sep 25;10(5):583-588. doi: 10.14744/nci.2023.36034. PMID: 37829757; PMCID: PMC10565758. [3]Nectin-4 as a Predictive Marker for Poor Prognosis of Endometrial Cancer with Mismatch Repair Impairment. Cancers (Basel). 20...
Characterization of Nectin-4 protein expression in non-small cell lung cancer patients Abstract # 35472 •# B014 INTRODUCTION • Nectin-4, a cell adhesion molecule from the Nectin-like family, is a validated tumor target overexpressed on the surface of cells in several cancers1. • Using ...
[5] Li, Kaiyue, et al. "Therapeutic prospects of nectin-4 in cancer: applications and value." Frontiers in Oncology 14 (2024): 1354543. [6] Kedashiro, Shin, et al. "Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent...
提示Nectin一4表达 的增高,可能对卵巢癌的发生、浸润及转移有一定的促进作用,监测Nectin.4 对评价卵巢癌的转移、指导治疗及判断预后可能具有重要价值。 关键词 卵巢肿瘤;Nectin.4;细胞黏附;RT-PCR;免疫组织化学 2 EXPRESSIONOFNECTIN.4IN OVARIANCANCER ANDITSCLINICAL SIGNIFICANCE Chai Postgraduate: Shouhui ...
[ 9 ]. McKean M, Baldini C, Verlingue L, Doger B, Falchook G, Italiano A, et al. Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression. Cancer Res 2022;82:CT025-...
Currently approved ADCs in breast cancer target HER2 or Trop-2. Enfortumab vedotin, an ADC targeting Nectin-4, a cell adhesion molecule, is approved in advanced/metastatic urothelial cancer. This study evaluated the expression landscape of Nectin-4 in breast cancer and its association with ...