[5] Deng, H., Shi, H., Chen, L. et al. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int 19, 106 (2019). [6] Liu R, Zh...
OBJECTIVE: Nectin-4 is a transmembrane protein belonging to the nectin family of immunoglobulin-like molecules which is found in the placenta and trachea under physiological conditions and its expression has been shown in many cancer types. We aimed to investigate for the 1st time nectin-4 ...
[6] Deng, H., Shi,H., Chen, L. et al. Over-expression of Nectin-4 promotes progression ofesophageal cancer and correlates with poor prognosis of the patients. CancerCell Int 19, 106 (2019).[7] Zhang J,Liu RJ, et al. 9MW2821, a nectin-4 antibody-drug conjugate (ADC), in patie...
et al. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int 19, 106 (2019). [6] Liu R, Zhao K, Wang K, Zhang L, Ma W, Qiu Z, Wang W. Prognostic value of nectin-4 in human cancers: A meta-...
Nectin 4蛋白高表达与高浆性卵巢癌患者生存期缩短相关,尤其见于腹膜粟粒状播散型肿瘤。 高Nectin 4肿瘤显示免疫相关基因(如HLA I类)表达降低,可能削弱抗肿瘤免疫反应。 染色体22q11/12区域基因表达减少,6q21区域基因缺失与Nectin 4高表达相关,提示特定基因异常驱动肿瘤进展。
[5] Li, Kaiyue, et al. "Therapeutic prospects of nectin-4 in cancer: applications and value." Frontiers in Oncology 14 (2024): 1354543. [6] Kedashiro, Shin, et al. "Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent...
[9].McKean M, Baldini C, Verlingue L, Doger B, Falchook G, Italiano A, et al. Abstract CT025: BT8009-100 phase I/II study of novel bi-cyclic peptide and MMAE conjugate BT8009 in patients with advanced malignancies associated with nectin-4 expression. Cancer Res 2022;82:CT025-CT. ...
Lin X, Hu H, Pan Y, Gao S. The prognostic role of expression of nectin-4 in esophageal cancer. Med Sci Monit. 2019;25:10089-10094. doi:10.12659/MSM.918288 Tanaka Y, Murata M, Shen C-H, Furue M, Ito T. Nectin4: a novel ther...
[6] Deng, H., Shi, H., Chen, L. et al. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int 19, 106 (2019). [7] Zhang J, Liu RJ, et al. 9MW2821, a nectin-4 antibody-drug conjugate (ADC), ...
结论:NECTIN4扩增是mUC患者对EV反应和长期生存的基因组预测指标。 NECTIN4Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer. J Clin Oncol. 2024 Jul 10;42(20):2446-2455. doi: 10.1200/JCO.23.01983. Epub 2024 Apr 24. PMID: 38657187; ...