Paraptosis is a caspase independent programmed cell death with similarities to apoptosis and necrosis. It is characterized by extensive cytoplasmic vacuolation involving swelling of the endoplasmic reticulum and mitochondria. Paraptotic cells lack the features of apoptosis, including nuclear fragmentation, ...
There are fundamental cellular processes, such as proliferation, survival, necrosis and apoptosis that play a role in physiological and pathological processes. These pathways are described and discussed in the light of cell mechanics. In this chapter, the concept of mechanical cell competition through ...
Paraptosis is a caspase independent programmed cell death with similarities to apoptosis and necrosis. It is characterized by extensive cytoplasmic vacuolation involving swelling of the endoplasmic reticulum and mitochondria. Paraptotic cells lack the features of apoptosis, including nuclear fragmentation, ...
Clinical similarities and differences of patients with X-linked lymphoproliferative syndrome type 1 (XLP-1/SAP deficiency) versus type 2 (XLP-2/XIAP defici... X-linked lymphoproliferative syndromes (XLP) are primary immunodeficiencies characterized by a particular vulnerability toward Epstein-Barr virus...
Apoptosis assays 1. Cytomorphological altercation 2. DNA fragmentation 3. Detection of caspases, cleaved substrate, regulators and inhibitors 4. Membrane altercations 5. Detection of Apoptosis in Whole Mounts 6. Mitochondrial assays Apoptosis significance/ Applications/ Roles ...
Since the discovery of cell apoptosis, other gene-regulated cell deaths are gradually appreciated, including pyroptosis, ferroptosis, and necroptosis. Necroptosis is, so far, one of the best-characterized regulated necrosis. In response to diverse stimul
Unlike necrosis, myocardial apoptotic cell death and the role of MiRNAs therein have been well documented. Apoptosis is a highly regulated process in which signaling is mediated by the mitochondria (Crow et al., 2004), regulated by a family of both proapoptotic and antiapoptotic member proteins ...
Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-alpha and interleukin 1. The role of tumor necrosis factor α (TNF-α) in the pathogenesis of autoimmune diabetes mellitus was tested in the nonobese mouse (NOD) model system. The ... ...
Another family member, “TNF-related apoptosis–inducing ligand” (TRAIL), similarly acts on death domain expressing DR4 and DR5 receptors. In addition to mediating antitumor effects, mice with deletion of TRAIL or its receptors develop autoimmune diseases. Analogous to Fas deletion, the absence of...
Goetz2,‡ & Josep V. Planas1 Ovulation is induced by the preovulatory surge of luteinizing hormone (LH) that acts on the ovary and triggers the rupture of the preovulatory ovarian follicle by stimulating proteolysis and apoptosis in the follicle wall, causing the release of the ...