Paraptosis is a caspase independent programmed cell death with similarities to apoptosis and necrosis. It is characterized by extensive cytoplasmic vacuolation involving swelling of the endoplasmic reticulum and mitochondria. Paraptotic cells lack the features of apoptosis, including nuclear fragmentation, ...
Negative signals include the absence of certain growth factors, cytokines, and hormones that can lead to failure of inhibition of death programs, thereby triggering apoptosis. In simple words, the withdrawal of factors causes loss of apoptotic suppression and subsequent activation of apoptosis. The fac...
Unlike apoptosis featured by cell shrinkage, DNA fragmentation, and membrane blebbing, necroptosis exhibits cell swelling and rupture of the plasma membrane [38]. Necroptosis is a form of nonapoptotic cell death and can be initiated by a series of factors, including death ligands, microbial infection...
Unlike necrosis, myocardial apoptotic cell death and the role of MiRNAs therein have been well documented. Apoptosis is a highly regulated process in which signaling is mediated by the mitochondria (Crow et al., 2004), regulated by a family of both proapoptotic and antiapoptotic member proteins ...
Apoptosis is induced in cells via distinct pathways, which may differ according to various stimuli and different cell types. One apoptotic stimulus is the activation of receptors such as the p55 tumor necrosis factor (TNF) receptor. These receptors transduce their apoptotic signals via a cytoplasmic...
Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis. Cell... CA Wilson,JL Browning - 《Cell Death & Differentiation》 被引量: 41发表: 2003年 Death of HT29 adenocarcinoma cells induced by TNF fam...
Another family member, “TNF-related apoptosis–inducing ligand” (TRAIL), similarly acts on death domain expressing DR4 and DR5 receptors. In addition to mediating antitumor effects, mice with deletion of TRAIL or its receptors develop autoimmune diseases. Analogous to Fas deletion, the absence of...
Goetz2,‡ & Josep V. Planas1 Ovulation is induced by the preovulatory surge of luteinizing hormone (LH) that acts on the ovary and triggers the rupture of the preovulatory ovarian follicle by stimulating proteolysis and apoptosis in the follicle wall, causing the release of the ...
apoptosis and senescence of endothelial cells and alteration of normal homeostasis [44]. A microcomputed tomography analysis showed the vessel percentage was significantly decreased and the distance between vessels, a marker of vascular destruction, was significantly increased in irradiated bones in a rat...
Stimulation of NO generation can cause oxidative stress leading to dysfunction in mitochondrial respiration and also block caspase-3 activity by nitrosylation, which may inhibit apoptosis and thereby promote necrosis [34]. Beyond the effects on the immune response, TNF-α has been associated with ...