Among these, apoptosis and necrosis are two distinct cell death pathways, and their detection and discrimination is vital in the drug discovery process and in understanding diverse biological processes. Although sensitive assays for apoptosis and necrosis are available, it is extremely difficult to ...
aUnder this option one windscreen, two tyres and demurrage will be covered for accidental damage. 在这扇选择一挡风玻璃之下,二轮胎和抗议为偶然损伤将报道。 [translate] aHONG 洪 [translate] afight against pollution 与污染的战斗 [translate] aapoptosis andnecrosis apoptosis andnecrosis [translate] ...
Apoptosis and oncotic necrosis in neuronal and glial cells have been documented in many neurological diseases. Distinguishing between these two major types of cell death in different neurological diseases is needed in order to better reveal the injury mechanisms so as to open up opportunities for ther...
Currently, the 2004 World Health Organization classification of pulmonary neuroendocrine tumors www.modernpathology.org is based on combined architectural patterns consi- dering the two most relevant morphological param- eters, that is, the mitotic index and the presence of necrosis, diagnosed by ...
To determine whether macrophages were activated, mouse liver sections were also stained with rat anti-mouse CD11b (also known as macrophage-1 antigen or Mac-1) antibodies identified by a goat anti-rat secondary antibody linked to horseradish peroxidase or with anti-tumor necrosis factor α (TNF...
Heterogeneity of tumor angiogenesis may lead to reduction of local effective blood flow, hypoxia, increased interstitial hydrostatic pressure in the tumor microenvironment and finally increased risk of tumor invasiveness and metastasis. Necrosis in the tumor on enhanced CT scan has been found to be an...
Accumulating evidence has revealed a strong association between obesity-linked insulin resistance and inflammation (2). Tumor necrosis factor-α (TNF-α), a prototypical pro-inflammatory cytokine, was upregulated in the epididymal fat of obese rodents, and neutralization of TNF-α ameliorated insulin...
Here we present an overview of different methods that can be used to discriminate apoptosis from necrosis, more in particular necroptosis, both in vivo and in vitro. Methods for necrotic cell death detection are summarized, and potential pitfalls of these methods are briefly discussed. Basically, ...
NecrosisProteolysisBiomarkerApoptosis and oncotic necrosis in neuronal and glial cells have been documented in many neurological diseases. Distinguishing between these two major types of cell death in different neurological diseases is needed in order to better reveal the injury mechanisms so as to open ...
Despite several possible sources such as apoptosis/necrosis of tumour cells, blood cells, lysed circulating tumour cells and active release of fcDNA by living cells (van der Vaart and Pretorius, 2008), tumour DNA constitutes a large proportion of fcDNA in cancer patients. There are conflicting ...