化学名 NCX-4016 分子式 C16H13NO7 CAS号 175033-36-0 结构式图片 SMILES CC(=O)OC1=CC=CC=C1C(=O)OC2=CC(CO[N+]([O-])=O)=CC=C2 INCHIKEY IOJUJUOXKXMJNF-UHFFFAOYSA-N 别名 2-(ACETYLOXY)-(3-(NITROXYMETHYL)PHENYL)BENZOIC ACID;BENZOIC ACID, 2-(ACETYLOXY)-, 3-((NITROOX...
关键词: NO 供体; N. 溴代琥珀酰亚胺; 合成; NCX-4016;环氧酶( COX); 间甲酚; 非甾体抗炎药J 英文摘要T heSynthesisofNitricOxide ・R eleasingNonsteroidalAnti-inflammatoryDrugNCX-4016ABSTRACTNonsteroidalanti—inflammatorydrugs(NSAIDs)arewidelyusedintheclinicaltreatmentoffever,painandinflammation.The...
一氧化氮阿司匹林(NCX-4016)体外抗氧 化作用 ChineseJournalofNewDrugs2006,Vo1.15No.8 金森病药物等)导致的药源性口干症及口咽区放 疗后引起的口干症状,而且随着用药时间的延长, 疗效显着提高.本研究表明,多数患者在用药1 周后,主观症状明显改善,并随着用药时间的延 ...
Chemischer Name NCX 4016 CAS No.175033-36-0 SummenformelNCX 4016 Molekulargewicht331.28 PSA107.65000 LogP3.06260 PubChemID119032 Synonyme2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester, 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester, 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate, NC...
NCX-4016加入反应体系,观察药物对反应体系内形成动力曲线的影响以及对LDL氧化的作用,同时以硫代巴比妥酸反应活性物(TBRAS)测定诱导LDL氧化前后过氧化脂质生成量的影响.结果:NCX-4016能够降低CD的最大生成量、延长潜伏期,降低LDL氧化产物丙二醛(MDA)的含量,并具有浓度依赖效应关系(P<0.05).在相同浓度条件下NCX-4016...
NCX-4016加入反应体系,观察药物对反应体系内形成动力曲线的影响以及对LDL氧化的作用,同时以硫代巴比妥酸反应活性物(TBRAS)测定诱导LDL氧化前后过氧化脂质生成量的影响.结果:NCX-4016能够降低CD的最大生成量,延长潜伏期,降低LDL氧化产物丙二醛(MDA)的含量,并具有浓度依赖效应关系(P<0.05).在相同浓度条件下NCX-4016...
NCX4016 (2 acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester, NicOx S.A., France) is an anti-thrombotic agent, chemically related to acetylsalicylic acid (ASA) and able to release NO. We tested the effects of NCX4016 and ASA on the release of the thromboxane (TX) A 2 metabolite TXB...
This review describes the pharmacological profile of the NO-donating aspirin, NCX 4016, by addressing principally the pharmacological activity in inflammation and cardiovascular models. Gastrointestinal safety is specifically addressed. The potential clinical use of NCX 4016 in vascular pathologies is also...
NCX 4016 is a nitric oxide (NO)-donating derivative of acetylsalicylic acid. NO and salicylate, in vivo metabolites of NCX 4016, were shown to be potential actors in controlling glucose homeostasis. In this study, we evaluated the action of NCX 4016 on the capacity of 3T3-L1 adipocytes to...
NCX 4016 is a nitric oxide (NO)-donating derivative of acetylsalicylic acid. NO and salicylate, in vivo metabolites of NCX 4016, were shown to be potential actors in controlling glucose homeostasis. In this study, we evaluated the action of NCX 4016 on the capacity of 3T3-L1 adipocytes to...