化学名 NCX-4016 分子式 C16H13NO7 CAS号 175033-36-0 结构式图片 SMILES CC(=O)OC1=CC=CC=C1C(=O)OC2=CC(CO[N+]([O-])=O)=CC=C2 INCHIKEY IOJUJUOXKXMJNF-UHFFFAOYSA-N 别名 2-(ACETYLOXY)-(3-(NITROXYMETHYL)PHENYL)BENZOIC ACID;BENZOIC ACID, 2-(ACETYLOXY)-, 3-((NITROOX...
Chemischer Name NCX 4016 CAS No.175033-36-0 SummenformelNCX 4016 Molekulargewicht331.28 PSA107.65000 LogP3.06260 PubChemID119032 Synonyme2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester, 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester, 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate, NC...
关键词: NO 供体; N. 溴代琥珀酰亚胺; 合成; NCX-4016;环氧酶( COX); 间甲酚; 非甾体抗炎药J 英文摘要T heSynthesisofNitricOxide ・R eleasingNonsteroidalAnti-inflammatoryDrugNCX-4016ABSTRACTNonsteroidalanti—inflammatorydrugs(NSAIDs)arewidelyusedintheclinicaltreatmentoffever,painandinflammation.The...
结果:NCX一4016能够降低CD的最大生成量,延长潜伏期,降低LDL氧化产物丙 二醛(MDA)的含量,并具有浓度依 赖效应关系(P<0.05).在相同浓度条件下NCX一4016的抗LDL氧化效应显着 高于阿司匹林(P<0.05).结论: NCX一4016对cu"诱导的LDL的氧化具有明显抑制作用. ...
TF activity (NCX4016 300 mol l 1 : 53.7±39.9%, n =4) and immunoreactive TF (NCX4016 300 mol l 1 : 93.9±7.9%, n =7), measured in the supernatant of stimulated cells, were also dose-dependently inhibited by NCX4016 but not by ASA. The present results indicate that NCX4016 ...
摘要 目的:探讨一氧化氮阿司匹林(NCX-4016)的体外抗氧化低密度脂蛋白的效应.方法:健康成人空腹12 h新鲜混合静脉血,离心取血浆.采用密度梯度超速离心法分离低密度脂蛋白(LDL),鉴定其纯度并检测其浓度.以Cu2+体外诱导LDL氧化,制备LDL体外氧化模型,采用紫外分光光度计于234nm监测LDL氧化过程中共轭二烯键(CD)的形成...
目的:探讨一氧化氮阿司匹林(NCX-4016)的体外抗氧化低密度脂蛋白的效应.方法:健康成人空腹12 h新鲜混合静脉血,离心取血浆.采用密度梯度超速离心法分离低密度脂蛋白(LDL),鉴定其纯度并检测其浓度.以Cu2+体外诱导LDL氧化,制备LDL体外氧化模型,采用紫外分光光度计于234nm监测LDL氧化过程中共轭二烯键(CD)的形成情况.将...
In cardiovascular models, NCX 4016 shows a better efficacy than aspirin in counteracting thromboembolism, myocardial infarction and vascular reactivity and remodelling (restenosis). This review describes the pharmacological profile of the NO-donating aspirin, NCX 4016, by addressing principally the ...
For example, NCX 4016 has been found to be much more effective than the parent aspirin in reducing aberrant crypt foci, a precancerous lesion, in a rat model of colorectal cancer [20] and in inducing cell perturbations and growth inhibition in a panel of colorectal cancer cell lines in ...
NCX 4016 is a nitric oxide (NO)-donating derivative of acetylsalicylic acid. NO and salicylate, in vivo metabolites of NCX 4016, were shown to be potential actors in controlling glucose homeostasis. In this study, we evaluated the action of NCX 4016 on the capacity of 3T3-L1 adipocytes to...