Antibiotic-perturbed microbiota and the role of probiotics Hania Szajewska Karen P. Scott Mary Ellen Sanders Nature Reviews Gastroenterology & Hepatology (2025) Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances Qiu Jiang Jie Liu Yan-Jiang Wang Signal Transducti...
limited targeting and result in unsatisfactory therapeutic outcomes. Here we report on artificial-enzyme-modifiedBifidobacterium longumprobiotics for reshaping a healthy immune system in inflammatory bowel disease. Probiotics can promote the targeting and retention of the biocompatible artificial enzymes to pers...
Microbial ecosystems (i.e. “microbiomes”) have become more common in public vernacular; with respect to the human microbiome, for example, the benefits and detriments of probiotics and antibiotics are becoming well-known by the general public. Growing widespread awareness of the human microbiome ...
Prebiotics must be selectively utilized and have adequate evidence of health benefit for the target host. Dietary prebiotics must not be degraded by the target host enzymes. *The figure shows candidate as well as accepted prebiotics in that levels of evidence currently vary, with FOS and GOS bein...
(the receptor for SARS-CoV-2 entry), β2-adrenoceptor, muscarinic M2 receptor, angiotensin II AT1receptor and the angiotensin 1–7 MAS receptor26. High levels of other autoantibodies have been found in some patients with COVID-19 more generally, including autoantibodies that target the tissue (...
et al. Effect of probiotics and triple eradication therapy on the cyclooxygenase (COX)-2 expression, apoptosis, and functional gastric mucosal impairment in Helicobacter pylori-infected Mongolian gerbils. Helicobacter 11, 10–20 (2006). Article CAS PubMed Google Scholar Piotrowski, J., Skrodzka,...
Therefore, with the increasing incidence of chronic liver disease4, effective therapies for HE remain an unmet medical need. Although various factors are involved in the pathogenesis of HE, ammonia is assumed to play a central role in this process, and remains a prime target for current ...
Moore, M. C.et al. Effect of hepatic denervation on peripheral insulin sensitivity in conscious dogs.Am. J. Physiol. Endocrinol. Metab.282, E286–E296 (2002). ArticleCASPubMedGoogle Scholar Christiansen, J. J.et al. Effects of cortisol on carbohydrate, lipid, and protein metabolism: studie...
R. et al. Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies. Sci. Transl. Med. 12, eaax0876 (2020). Article CAS PubMed PubMed Central Google Scholar Harimoto, T. et al. Rapid screening of engineered microbial therapies in a 3D multicellular model. Proc. ...
One other striking advantage for nanomedicines is their greater propensity to passively target, and accumulate in, tumour tissues through the enhanced permeability and retention (EPR) effect. This phenomenon is based on poor lymphatic drainage of solid tumours combined with leaky tumour vessels that con...