Nature Reviews Drug Discovery is a journal for people interested in drug discovery and development. It features reviews, news, analysis and research highlights.
Multiple protein isoforms arise from most genes by alternative RNA splicing and other mechanisms, but these isoforms are often neglected in drug discovery. This Review discusses the modes of action of emerging therapeutics that focus on protein isoforms as well as how isoforms can serve as biomarkers...
The company landscape for artificial intelligence in large-molecule drug discovery Navraj S. Nagra Lieven van der Veken Matej Macak From the Analyst's Couch29 Aug 2023 The R&D landscape for infectious disease vaccines Jianying Yue Yuehua Liu ...
In this Review, Mercola and colleagues summarize the latest techniques for systematic drug repurposing and re-engineering, which could increase the pace, efficiency and cost-effectiveness of drug discovery for the treatment of cardiovascular disease. Mena Abdelsayed , Eric J. Kort & Mark Mercola ...
In June 2006, the tyrosine kinase inhibitor dasatinib (Sprycel; Bristol-Myers Squibb) was approved by the US FDA for the treatment of adults with chronic myeloid leukaemia and Philadelphia-chromosome-positive acute lymphoblastic leukaemia with resistance
Compounds that exhibit a covalent mechanism of action are typically avoided in drug discovery programmes, largely owing to safety concerns. Here, Singh and colleagues present the pharmacological advantages offered by covalent drugs and discuss strategies
Vertex’s first-in-class suzetrigine could soon usher in a new class of analgesic. Katie Kingwell News12 Dec 2024 Previouspage page1 page2 page3 … page252 Nextpage Nature Reviews Drug Discovery (Nat Rev Drug Discov)ISSN1474-1784(online)ISSN1474-1776(print)...
Functional dynamics of G protein-coupled receptors reveal new routes for drug discovery Recent advances in structural biology techniques and computational simulations have enhanced our understanding of the conformational dynamics of G protein-coupled receptors and their interactions with ligands. This Review...
et al. Discovery and development of respirable antisense therapeutics for asthma. Antisense Nucleic Acid Drug Dev. 12, 177–181 (2002). Article CAS PubMed Google Scholar Morishita, R., Tomita, N., Kaneda, Y., & Ogihara, T. Molecular therapy to inhibit NF-κB activation by transcription ...
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