Nature Reviews Drug Discovery is a journal for people interested in drug discovery and development. It features reviews, news, analysis and research highlights.
First-in-class versus best-in-class: an update for new market dynamics Lindsay Spring Kunle Demuren John Wu From the Analyst's Couch24 Apr 2023 Previouspage page1 page2 page3 … page14 Nextpage Nature Reviews Drug Discovery (Nat Rev Drug Discov)ISSN1474-1784(online)ISSN1474-1776(print)...
Collection|22 January 2024 AI in health care The use of artificial intelligence (AI), including machine learning and large language models, is revolutionizing health care, from drug discovery and development, through to applications in the risk stratification, diagnosis, imaging, monitoring, prognosticat...
Compounds that exhibit a covalent mechanism of action are typically avoided in drug discovery programmes, largely owing to safety concerns. Here, Singh and colleagues present the pharmacological advantages offered by covalent drugs and discuss strategies
In June 2006, the tyrosine kinase inhibitor dasatinib (Sprycel; Bristol-Myers Squibb) was approved by the US FDA for the treatment of adults with chronic myeloid leukaemia and Philadelphia-chromosome-positive acute lymphoblastic leukaemia with resistance
Can non-canonical amino acids open up non-canonical drug discovery opportunities? Jason Chin, head of Cambridge’s Centre for Chemical & Synthetic Biology and CSO of Constructive Bio, discusses the role for unnatural amino acids in biologic therapies. ...
Nature Reviews Drug Discovery volume 21, pages 655–675 (2022)Cite this article 70k Accesses 176 Citations 112 Altmetric Metrics details Abstract Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. ...
Nature Reviews Drug Discovery volume 21, pages 379–399 (2022)Cite this article 29k Accesses 398 Citations 43 Altmetric Metrics details Abstract The field of extracellular vesicle (EV) research has developed rapidly over the last decade from the study of fundamental biology to a subject of ...
Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology. Featured DNA-encoded chemical libraries on stage DNA-encoded chemical libraries were postulated in the early 1990s, but ...