The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Polθi) class wi
Abbreviations: Veh., vehicle control; MOG, myelin oligodendrocyte glycoprotein; MBP, myelin basic protein. Two independent cohorts of mice from multiple litters were used for the experiments in this figure. Data represent mean ± SEM analysed by one-way ANOVA with Dunnett multiple comparison between...
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4d). This suggests that this interaction is crucial for maintained protein function. However, a “mild” mutation of Gln142, Q142N, had no significant change in transport activity in our assays. In contrast, in a previous study mutagenesis of the equivalent residue in rat VMAT2 to alanine ...
“Lamb’s Quarter: (also known as goosefoot) The leaves of lamb’s quarter are excellent added to lettuce salads or cooked and used as a replacement for spinach. Lamb’s quarter seeds are also edible. They are a good source of protein and vitamin A. ...
Resistance to stress is a key determinant for mammalian functioning. While many studies have revealed neural circuits and substrates responsible for initiating and mediating stress responses, little is known about how the brain resists to stress and prev
3D). Furthermore, immunoblot analysis in T24 spheroids revealed a significant increase in the total JAK1 protein expression (Supplementary Fig. 9C). However, we were unable to detect phosphorylated form of JAK1 (pJAK1) by immunoblot analysis. Thus, we performed Reverse Phase Protein Array (...
(HSR) is an isogenic model, in which all theEGFRvIIIamplicons reside on chromosomal HSRs, at the same mean copy number with the same DNA sequence (Extended Data Fig.7a)28. Importantly, the heterogeneity ofEGFRvIIIcopy number in GBM39-EC correlates with the heterogeneity of EGFRvIII protein ...
4d). This suggests that this interaction is crucial for maintained protein function. However, a “mild” mutation of Gln142, Q142N, had no significant change in transport activity in our assays. In contrast, in a previous study mutagenesis of the equivalent residue in rat VMAT2 to alanine ...
Mapping these mutations onto the rpoB protein structure revealed that high-level resistance often involves disruption of the interactions with the rigid napthol ring while mutations at positions that contact the ansa bridge had more variable effects, potentially due to increased structural flexibility in ...