Controlling matter one molecule at a time is the ultimate goal of nanotechnology. Here, the authors show that it is possible to use a scanning tunnelling microscope to measure and influence the outcome of a single-molecule reaction with multiple competing outcomes. ...
The functions of biomolecular condensates are thought to be influenced by their material properties, and these will be determined by the internal organization of molecules within condensates. However, structural characterizations of condensates are chall
Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial oxidation and lipid accumulation that is dependent on prior wake and
Recombinant adeno-associated viruses (rAAVs) have emerged as promising gene therapy vectors due to their proven efficacy and safety in clinical applications. In non-human primates (NHPs), rAAVs are administered via suprachoroidal injection at a higher do
Here, the authors develop a single-cell drug discovery approach and identify a compound that tunes bacterial phenotypic variation. This enhances the activity of anti-tubercular drugs against the pathogen. Maxime Mistretta , Mena Cimino & Giulia Manina Article 08 May 2024 | Open Access ...
Fluorescence imaging in the second near-infrared (NIR-II) window enables deep-tissue imaging with high resolution and improved contrast by taking advantage of the reduced light scattering and tissue autofluorescence in this region of the spectrum. NIR-II fluorescence imaging uses photoluminescent contrast...
Full size image To further characterize the heterogeneous population of proliferating cells that may contain stem or progenitor cells, we performed scRNA-seq of viable (DAPI-) GFP+cells isolated by fluorescent-activated cell sorting (FACS) from the distal lung of SRC mice at day 2 and 3 after...
realize this vision, polycyclic aromatic hydrocarbon (PAH)-type luminophores possessing a largeπ-conjugate plane come into our sights32,33. The highly stable dimer formed in these molecular systems due to the strongπ-πinteraction between PAH groups may break the tether of crystallization and be...
Metal-organic framework (MOF) glasses are an emerging class of glasses which complement traditional inorganic, organic and metallic counterparts due to their hybrid nature. Although a few zeolitic imidazolate frameworks have been made into glasses, how t
One of the critical factors determining the performance of neural interfaces is the electrode material used to establish electrical communication with the neural tissue, which needs to meet strict electrical, electrochemical, mechanical, biological and m