As an EMBO and HFSP fellow in Matthew Freeman’s lab at the University of Oxford, she looked at the role of TNF signalling in lipid metabolism and neurodegeneration. She also contributed to projects centred around understanding the role of a pseudoprotease in ERAD. At the University of Oxford...
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These metabolites are involved in the metabolism of amino acids, nucleotides, nitrogen, and lipids, among others. Our study consisted of two Phase I trials (CA209-038, NCT01621490; CA209-009, NCT01358721), which included 78 patients with advanced melanoma and 91 patients with metastatic RCC ...
Community structure and the metabolism through reconstruction of microbial genomes from the environment. Nature. 428: 37 – 43.http://dx.doi.org/10.1038/nature02340PMid:14961025 Uchiyama T, Abe T, Ikemura T, Watanable K (2005). Substrate induced gene–expression screening of environmental ...
PIK3CAis one of the most frequently mutated genes in cancer; the PI3K pathway is altered in a large number of cancer types, driving cell signalling, growth and metabolism, and PI3K inhibitors have been in development for over four decades. ...
Gut microbiota carcinogen metabolism causes distal tissue tumours A spatial expression atlas of the adult human proximal small intestine A nebular origin for the persistent radio emission of fast radio bursts Multimodal approach steps up the search for axion insulators ...
metabolism. SRLs might have a negative influence on glucose metabolism, but generally with marginal clinical relevance and most frequently in patients who do not have biochemical control of the disease.6By contrast, pegvisomant usually has beneficial effects on glucose metabolism.6Blood glucose and Hb...
M. mTOR signaling in growth, metabolism, and disease. Cell 168, 960–976 (2017). Article CAS PubMed PubMed Central Google Scholar Hua, H. et al. Targeting mTOR for cancer therapy. J. Hematol. Oncol. 12, 71 (2019). Article PubMed PubMed Central Google Scholar Hudes, G. et al....
(PCCAandPCCB, respectively)1. PCC is a mitochondrial enzyme that catalyses the conversion of propionyl-CoA to methylmalonyl-CoA in the propionate metabolism pathway (Fig.1a). Deficiencies in PCC lead to an accumulation of toxic metabolites, including propionyl-CoA and organic acids, such as 2-...
Insulin action in brain regulates systemic metabolism and brain function. Diabetes 63, 2232–2243 (2014). Article PubMed PubMed Central Google Scholar Kulkarni, R. N. et al. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to ...