同时,该递送策略在人血中具有类似的功能,或可应用于脂质体以外的药物递送系统上。 参考论文:Brain-targeted drug delivery by manipulating protein corona functions,Nature Communicationsvolume 10, Article number: 3561 (2019) ,Published: 08 August 2019,https://www./articles/s41467-019-11593-z...
pertains to the number of precursor peptides encoded per BGC, with some Bacillota BGCs encoding >10 precursor peptides (Supplementary Fig.5). Actinomycetota BGCs also encode a predicted Fe-dependent alcohol dehydrogenase (Pfam27identifier PF00465), while Bacillota BGCs encode a different class of...
10- me+-THF (Fig.2f), the mitochondrial folate cofactor that is generated by redox-mediated MTHFD2 (Supplementary Fig.2g). Interestingly, the KO cells also have slightly, albeit not significantly, reduced THF and 5,10-me-THF (Fig.2f), which may suggest a primary mitochondrial localization...
主要研究方向:气候变化和人类活动对水文极端事件(洪水、干旱、旱涝急转等)的影响、水-粮食-能源系统的耦合、机器学习在水文领域的应用以及深度不确定环境下的稳健决策分析等。以第一及(或)通讯作者在Nature Communications (2019)、Science ...
主要研究方向:气候变化和人类活动对水文极端事件(洪水、干旱、旱涝急转等)的影响、水-粮食-能源系统的耦合、机器学习在水文领域的应用以及深度不确定环境下的稳健决策分析等。以第一及(或)通讯作者在Nature Communications (2019)、Science ...
Molecular memory with downstream logic processing exemplified by switchable and self-indicating guest capture and release Brian Daly Thomas S. Moody A. Prasanna de Silva Nature Communications(2019) Binary atomic silicon logic Robert A. Wolkow
Baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been widely used as a bioinsecticide and a protein expression vector. Despite their importance, very little is known about the structure of most baculovirus proteins. Here, we
复旦大学基础医学院占昌友研团队设计了一种新颖的脑靶向脂质体药物,血液循环过程中可精准“钓”取内源性载脂蛋白并维持其生物活性,实现高效的脑靶向药物递送。8月8日,相关研究成果在线发表于《Nature Communications》。 脂质体是当前临床应用最为广泛的一类纳米药物载体。靶向脂质体药物的相关研究在近40年时间内十分活...
The cell is constructed by higher-order structures and organelles through complex interactions among distinct structural constituents. The centrosome is a membraneless organelle composed of two microtubule-derived structures called centrioles and an amor
The largest source of uncertainty is the scarcity of data on cation concentration from non-ice sheet glaciers outside of Asia (43 glaciers and 3561 samples in Asia versus 20 glaciers and 1080 samples in the rest of the world; Fig.1Aand Table1). ...