Please note that the use of these tools, or any other service, is not a requirement for publication, nor does it imply or guarantee that editors will accept the article, or even select it for peer review.
Nature Cell Biology volume 23, pages 552–563 (2021)Cite this article 11k Accesses 61 Citations 44 Altmetric Metrics details Abstract The fusion of CRISPR–Cas9 with cytidine deaminases leads to base editors (BEs) capable of programmable C-to-T editing, which has potential in clinical ...
2023年3月3日,华东师范大学/中国医学科学院苏州系统医学研究所张晓辉,华东师范大学钟涛、李大力在Nature Communications期刊发表了题为:Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD 的研究论文。 该研究通过融合单链DNA结合蛋白Rad51DBD以及TadA-8e,开发了超高活性的腺嘌...
2023年4月,中国科学院遗传与发育生物学研究所高彩霞团队在Nature Biotechnolgy期刊发表了题为:Precise integration of large DNA sequences in plant genomes using PrimeRoot editors 的研究论文。 该研究将团队之前开发的ePPE(Engineered Plant Prime Editor)与刘如谦团队开发的epegRNA(Engineered pegRNA)结合,在植物细胞...
碱基编辑器hyCBEs(Nature Cell Biology,2020),构建了一系列不依赖天然胞嘧啶脱氨酶家族的“精准且安全”的新型胞嘧啶碱基编辑器Td-CGBE/Td-CBEs(Nature Biotechnology,2022),编辑窗口为1-2碱基的高精度的腺嘌呤碱基编辑器ABE9(Nature Chemical Biology,2022)和多个拓展靶向范围的PAM灵活的ABE系统(Protein &Cell,...
Nature Cell Biology26,294–304 (2024)Cite this article 7185Accesses 16Citations 11Altmetric Metrics Abstract Base editors (BEs) introduce base substitutions without double-strand DNA cleavage. Besides precise substitutions, BEs generate low-frequency ‘stochastic’ byproducts through unclear mechanisms. He...
4. Zhang, X. et al. Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain. Nature cell biology 22, 740-750 (2020). 5. Chen, L. et al. Re-engineering the adenine deaminase TadA-8e for efficient and specific...
4. Zhang, X. et al. Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain. Nature cell biology 22, 740-750 (2020). 5. Chen, L. et al. Re-engineering the adenine deaminase TadA-8e for efficient and specific...
2023年4月,高彩霞研究员团队在Nature Biotechnolgy期刊发表了题为Precise integration of large DNA sequences in plant genomes using PrimeRoot editors的研究论文。 该研究将团队之前开发的ePPE(Engineered Plant Prime Editor)与美国博德研究所刘如谦团队开发的epegRNA(Engineered pegRNA)结合,在植物细胞内建立了dual-eP...
2023年4月,中国科学院遗传与发育生物学研究所高彩霞团队在Nature Biotechnolgy期刊发表了题为:Precise integration of large DNA sequences in plant genomes using PrimeRoot editors的研究论文。 该研究将团队之前开发的ePPE(Engineered Plant Prime Editor)与刘如谦团队开发的epegRNA(Engineered pegRNA)结合,在植物细胞内...