The field of chemical biology has changed dramatically over the past 20 years. Here, we speak to Sarah E. O’Connor, Benjamin F. Cravatt and Chengqi Yi about the major changes that have affected the field, the advances that have affected them and their research, and their thoughts about th...
其中胞嘧啶碱基编辑器(Cytosine base editor, CBE)由胞嘧啶脱氨酶,Cas9切口酶(nickase Cas9, nCas9)和尿嘧啶糖基化酶抑制剂(uracil DNA glycosylase inhibitor,UGI)组成,可以诱导高效C-to-T碱基转换。然而,CBE的宽编辑窗口容易导致...
Base editors chemically convert one nucleotide base to another. The development of the first base editor eight years ago marked a major leap forward toward the use of genome-editing technologies for correcting human genetic diseases and as a powerful tool for molecular biology. ...
生物-生化与分子生物学领域学术期刊——《Nature Chemical Biology》,为化学生物学界发表顶级原创研究和评论提供了一个高知名度的论坛。 ISSN:1552-4450 01 影响因子 Nature Chemical Biology近年来影响因子持续上涨,2021-2022年度影响因子达到16.174。 近期想要快速发表文章的同学可以添加佩普科研助理咨询,佩普学术是专门为...
Nature Chemical Biology! BRL medicine team developed a highly accurate and efficient cytosine base editor2024-04-02On March 29,2024, BRL medicine, in cooperation with the team of Mingyao Liu, Dali Li, and Liren Wang of East China Normal University and the research group of Fanyi Zeng from ...
Nature Chemical Biology !邦耀生物团队发文,开发出精准高效的胞嘧啶碱基编辑器 2024年3月29日,聚焦于基因和细胞治疗的上海邦耀生物科技有限公司(以下简称“邦耀生物”)与华东师范大学刘明耀、李大力、王立人团队以及上海交通大学基础医学院曾凡一课题组合作,在国际知名期刊Nature Chemical Biology杂志发表了题为“...
6. Chen, L. et al. Engineering a precise adenine base editor with minimal bystander editing. Nature chemical biology 19, 101-110 (2023). 7. Yang, L. et al. Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. ...
6. Chen, L. et al. Engineering a precise adenine base editor with minimal bystander editing. Nature chemical biology 19, 101-110 (2023). 7. Yang, L. et al. Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. ...
(Nature Biotechnology,2020)、超高活性的胞嘧啶碱基编辑器hyCBEs(Nature Cell Biology,2020),构建了一系列不依赖天然胞嘧啶脱氨酶家族的“精准且安全”的新型胞嘧啶碱基编辑器Td-CGBE/Td-CBEs(Nature Biotechnology,2022),编辑窗口为1-2碱基的高精度的腺嘌呤碱基编辑器ABE9(Nature Chemical Biology,2022)和多个拓展...
nature chemical biology 期刊发表了题为: an engineered hypercompact crispr-cas12f system with boosted gene-editing activity 的研究论文 . 该研究开发了一种工程化ascas12f系统—— enascas12f ,其大小仅为spcas9的三分之一,enasc...