Aging is associated with increased levels of inflammation and metabolic changes. Here authors compare B cells from young and elderly donors and see immunometabolic changes and assess the impact of increased lactate production on the immune responses at different ages. ...
Nat. Aging 1, 870–879 (2021). Article PubMed PubMed Central Google Scholar Wang, T. W. et al. Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes. Nature 611, 358–364 (2022). Article CAS PubMed Google Scholar Lin, M. J. et al. Cancer vaccines: the ...
Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several recently discovered compounds that extend the healthspan and lifespan of model organisms decelerate pathways that govern the aging process. Among these geroprot
Amuc_1409 increased intestinal stem cell (ISC) proliferation and regeneration in ex vivo intestinal organoids and in vivo models of radiation- or chemotherapeutic drug-induced intestinal injury and natural aging with male mice. Mechanistically, Amuc_1409 promoted E-cadherin/β-catenin complex ...
Apple derived exosomes improve collagen type I production and decrease MMPs during aging of the skin through downregulation of the NF-κB pathway as mode of action. Cells. 2022. https://doi.org/10.3390/cells11243950. Article PubMed PubMed Central Google Scholar Yang S, Lu S, Ren L, Bian...
724 Journal Impact Factor 223.679 74.449 70.670 59.102 57.618 54.301 54.000 51.848 51.273 44.019 43.704 43.351 43.070 41.037 40.443 38.887 38.296 36.216 35.386 34.648 34.106 34.024 34.024 33.407 33.250 33.162 33.069 32.274 31.864 31.583 30.641 30.628 28.755 28.467 28.295 28.245 27.778 27.604 27.516 26.922 ...
Nature Aging同期对该研究刊发了Research Briefing(研究简报),加拿大维多利亚大学Marie-Ève Tremblay教授撰写评论,认为该研究非常有价值,增进了人们对小胶质细胞老龄化及其如何影响记忆的理解(This represents a highly relevant paper that improves our understanding of microglial aging and its impact on memory)。
The two years line is equivalent to journal impact factor ™ (Thomson Reuters) metric. Cites per documentYearValue Cites / Doc. (4 years) 1999 9.501 Cites / Doc. (4 years) 2000 9.547 Cites / Doc. (4 years) 2001 9.951 Cites / Doc. (4 years) 2002 11.016 Cites / Doc. (4 years...
(SAC), the signaling system of higher organisms including the human that monitors the proper attachment of chromosomes to microtubules during cell division. Defects in this process result in genome instability, aneuploidy, premature aging, and cancer. APC/C roles in the SAC require its activation ...
breakdown occurs not just at the moment of injury, but in interaction with all the things of the world. Even if it happens suddenly, as with a broken arm or a stroke, as opposed to the almost imperceptibly slow breakdown of aging, the breakdown is a process unforeseeable at the time of...