For over 300 million years, insects have relied on symbiotic microbes for nutrition and defence. However, it is unclear whether specific ecological conditions have repeatedly favoured the evolution of symbioses, and how this has influenced insect diversi
Nature 569, 663–671 (2019). Article CAS PubMed PubMed Central Google Scholar Mars, R. A. T. et al. Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome. Cell 182, 1460–1473 (2020). Article CAS PubMed PubMed Central Google Scholar Gilbert, J....
nu = n − 1 + 0.002, wherenwas equivalent to the number of response traits). If the mixing properties of the MCMC chain were poor, which was often the case for binomial response variables, we examined parameter expanded priors (V = ...
Hu, M. M. et al. Virus-induced accumulation of intracellular bile acids activates the TGR5–β-arrestin–SRC axis to enable innate antiviral immunity.Cell Res.29, 193–205 (2019). ArticleCASGoogle Scholar Latorraca, N. R., Venkatakrishnan, A. J. & Dror, R. O. GPCR dynamics: structu...
E. & Rossi, N. F. Hypertension associated with fructose and high salt: renal and sympathetic mechanisms. Nutrients 11, 569 (2019). CAS PubMed Central Google Scholar Griep, L. M. O. et al. Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP study. ...
Full-length human GPBAR with thermostabilized cytochrome b562RIL (BRIL) introduced into the N terminus was coexpressed with Gs protein in Spodoptera frugiperda (Sf9) insect cells. Active complexes were readily formed by the addition of excess high-affinity agonist P395 and the nanobody Nb35. b...
Biomarker analysis of a subset of 2016 survivors (n = 16) resulted in a moderate, significant (p < 0.05) decrease in IL-6, as well as a large, significant (p < 0.01) increase in CRP. See Figure 2 and Figure 3. Figure 2. Pre-Post Changes in PROMIS Anxiety, Depression and Sleep ...
Sodium intake restriction reduces blood pressure, particularly in patients with hypertension, and the Dietary Approaches to Stop Hypertension (DASH) diet is the most effective dietary approach to prevent hypertension and to reduce blood pressure in individuals with pre-hypertension or hypertension. ...
Schliesser, A., Picqué, N. & Hänsch, T. W. Mid-infrared frequency combs. Nat. Photon. 6, 440–449 (2012). Article ADS CAS Google Scholar Ycas, G. et al. High-coherence mid-infrared dual-comb spectroscopy spanning 2.6 to 5.2 μm. Nat. Photon. 12, 202–208 (2018). Article...
Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, and AER-like cells are suggested to be re-formed to initiate limb regeneration. Paradoxically, the presence of AER in the axolotl, a primary mo