Nature volume 554, pages 317–322 (2018)Cite this article 78k Accesses 717 Citations 430 Altmetric Metrics details Abstract The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine has attracted enormous interest in mental health research owing to its rapid antidepressant actions, but its ...
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Urban areas are the largest source of pollutants that directly or indirectly will end up in the air, soil, and water. It is paramount to find solutions to reduce the impact of pollution on climate change, ecosystem services, biodiversity loss, and human
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For over 300 million years, insects have relied on symbiotic microbes for nutrition and defence. However, it is unclear whether specific ecological conditions have repeatedly favoured the evolution of symbioses, and how this has influenced insect diversi
Membrane fusion and budding mediate fundamental processes like intracellular trafficking, exocytosis, and endocytosis. Fusion is thought to open a nanometer-range pore that may subsequently close or dilate irreversibly, whereas budding transforms flat me
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(Fig.3d). The WTTfCut contains the combination of His/Phe in positions of 224 and 228 below W195 and this pair fixes the W195-bareing loop and its indole ring in the C-type conformation. This leads to a narrower substrate entering portal (circled in Fig.4a). The same structural ...