Gaudelli, N. M. et al. Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage. Nature 551, 464–471 (2017). Article CAS Google Scholar Li, X. et al. Base editing with a Cpf1–cytidine deam
Gaudelli, N. M. et al. Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage. Nature551, 464–471 (2017). Article ADS CAS Google Scholar Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Programmable editing of a target base...
Minimal liquid discharge (MLD) is an alternative strategy to ZLD, which is essentially brine volume reduction followed by disposal. ZLD and MLD have current and potential applications in the desalination, energy, mining and semiconductor industries. Emerging technologies for brine concentration and crysta...
Elongin is a heterotrimeric elongation factor for RNA polymerase (Pol) II transcription that is conserved among metazoa. Here, we report three cryo-EM structures of human Elongin bound to transcribing Pol II. The structures show that Elongin subunit ELOA