Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have a high specific metabolic rate, play an essential role in the long-term regulation of arterial blood pressure. In this review, we discuss the emerging role of ren
Proteome integrity depends on the ubiquitin–proteasome system to degrade unwanted or abnormal proteins. In addition to the N-degrons, C-terminal residues of proteins can also serve as degradation signals (C-degrons) that are recognized by specific culli
The Dietary Approaches to Stop Hypertension (DASH)-Sodium trial examined the effect of ~30 days of 50, 100, or 150 mmol of sodium intake on blood pressure using a randomized, crossover study design32. The trial demonstrated that higher sodium intake significantly increased blood pressure. A ...
Neutrophils are the most abundant leukocyte in humans and provide a critical early line of defense as part of our innate immune system. We perform a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, differentiation
a–dAs-deposited1on the Ag(100). The long axis of a1monomer is marked with yellow dash line.e–hAfter annealing at 573 K for 30 min, most1transformed to2.i–lAfter annealing at 623 K for 30 min, most of the molecules transformed to3.a,e,iLarge scale andb,f,jzoomed in...
n = 10. Error bars, S.E.M. Full size image Since the vomeronasal stimulatory activity was present in the cell lysate, but not in plasma (Fig. 1e), we performed two-step column purification of the cell lysate using ion-exchange DEAE (Fig. 1f) and reverse phase C4 (Fig. 1g) ...
7D6 interacts with the SARS-CoV-2 RBD mainly through eight hydrogen bonds and van der Waals contacts between HCDR1-3 and residues 346–355 and 466–471 of the RBD (Fig.3j); RBD residues T470, Y351, R346, R466, and R355 are critical for these interactions (Fig.3k). For 6D6, th...
assumes an increase in total organic carbon burial with the rise of land plants from ~470 Ma onwards, generating a rise inpO2at this time (green dashed line in Fig.3). The MAGic model, on the other hand, assumes that land plant material makes a relatively small contribution to total ...
(T;n=51) compared with normal ovarian surface epithelial cells (OSECs) and fallopian tube secretory epithelial cells (FTSECs) (N;n=73) (*P<0.05, **P<0.01, ***P<0.001). (c) Gene expression (primary EOCs and normal tissue). Boxplots of The Cancer Genome Atlas (TCGA) Affymetrix U13...