AML are caused by different mutations, and we have shown that blast cells adopt subtype-specific gene regulatory networks (GRNs) maintaining the leukemic phenotype7,8. It is largely unknown how GRNs in LSCs compare to those of blast cells as the latter dominate the transcriptional signature in ...
Nature volume 611, pages 387–398 (2022)Cite this article 27k Accesses 75 Citations 131 Altmetric Metrics details Abstract Acute myeloid leukaemia (AML) represents a set of heterogeneous myeloid malignancies, and hallmarks include mutations in epigenetic modifiers, transcription factors and kinases1,2...
Urban areas are the largest source of pollutants that directly or indirectly will end up in the air, soil, and water. It is paramount to find solutions to reduce the impact of pollution on climate change, ecosystem services, biodiversity loss, and human
Harris, M. L. et al. Patterns of contraceptive use among young Australian women with chronic disease: findings from a prospective cohort study.Reprod. Health19, 111 (2022). ArticlePubMedPubMed CentralGoogle Scholar Baker, R. J., Mark, P. B., Patel, R. K., Stevens, K. K. & Palmer...
485 23,757 3,569 7,293 9,022 28,522 28,522 4,044 16,951 4,282 8,343 8,343 738 1,941 9,811 6.436 6.425 6.424 6.404 6.403 6.402 6.402 6.402 6.400 6.395 6.394 6.393 6.391 6.391 6.381 6.381 6.380 6.365 6.361 6.355 6.355 6.350 6.349 6.342 6.336 6.333 6.333 6.330 6.312 6.309 6.305 ...
2022 389 2023 485 Citations per document Cites / Doc. (4 years)Cites / Doc. (3 years)Cites / Doc. (2 years)19992002200520082011201420172020202304812162024 This indicator counts the number of citations received by documents from a journal and divides them by the total number of documents publish...
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Rowald, A. et al. Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.Nat. Med.28, 260–271 (2022). ArticleCASPubMedGoogle Scholar Kathe, C. et al. The neurons that restore walking after paralysis.Nature611, 540–547 (2022)....
Analysis of electron density maps allowed the identification of a second Fe2+ in the LH domain, coordinated by residues His595, Asp597, Asp611 and His613 (Fig. 3b). Metal ion coordination stabilizes the flexible capping loop 590–610 into a conformation that completely plugs the LH catalytic ...