Hypertension is a leading risk factor for disease burden worldwide. The kidneys, which have a high specific metabolic rate, play an essential role in the long-term regulation of arterial blood pressure. In this review, we discuss the emerging role of ren
N. Engl. J. Med. 344, 3–10 (2001). This study shows that combining the DASH diet with a low sodium (50 mmol per day) intake led to significant reductions in systolic BP both in persons with hypertension and in those without hypertension compared with persons who consumed a high sodium...
Proteome integrity depends on the ubiquitin–proteasome system to degrade unwanted or abnormal proteins. In addition to the N-degrons, C-terminal residues of proteins can also serve as degradation signals (C-degrons) that are recognized by specific culli
The Dietary Approaches to Stop Hypertension (DASH)-Sodium trial examined the effect of ~30 days of 50, 100, or 150 mmol of sodium intake on blood pressure using a randomized, crossover study design32. The trial demonstrated that higher sodium intake significantly increased blood pressure. A ...
n = 10. Error bars, S.E.M. Full size image Since the vomeronasal stimulatory activity was present in the cell lysate, but not in plasma (Fig. 1e), we performed two-step column purification of the cell lysate using ion-exchange DEAE (Fig. 1f) and reverse phase C4 (Fig. 1g) ...
Animals are not simple input-output machines. Their responses to even very similar stimuli are variable. A key, long-standing question in neuroscience is to understand the neural correlates of such behavioral variability. To reveal these correlates, beha