On the other hand, recently, N-methyl-D-aspartate (NMDA) receptor antagonists have become a strong alternative, which has been approved to be effective in treatment of moderate to severe type of AD. Within the past few years, some pharmaceuticals have become available for clinical use; however...
The NMDA receptor antagonists mainly work by increasing the influx of calcium ions into the neuronal cells, thus improving neurotransmission [8]. This class suffers from some side effects, such as irritation, headache, gastrointestinal problems, and dizziness [4]. Both classes, approved by the FDA...
The currently approved treatments for AD are limited to a cholinesterase inhibitor and a low-affinity NMDA receptor antagonist. Nevertheless, the treatments are rather symptomatic than curative [2,6]. In this context, bioactive products from Brazilian Caatinga may have a significant pharmacological ...
Antidepressant-like effect of the leaves of Pseudospondias microcarpa in mice: evidence for the involvement of the serotoninergic system, NMDA receptor complex, and nitric oxide pathway. BioMed Res Int. 2015. https://doi.org/10.1155/2015/397943. Article PubMed PubMed Central Google Scholar ...
another tropane derivative which functions serotonin receptor antagonist. It is used as antiemetic and as analgesic in fibromyalgia [123]. N-Butylation of scopolamine yields N-butylscopolamine which is on the WHO “List of Essential Medicines”[124] and is used as anti-spasmodic and used to ...
Currently, only a few drugs, which function as acetylcholinesterase (AChE) inhibitors or N-methyl-D-aspartate (NMDA) receptor antagonists, are available to alleviate symptoms.doi:info:doi/10.2174/1568026619666190201153257Wu, XiaoaiCai, HuaweiPan, Lili...
(NMDA)receptor antagonists,the former representative drug is donepezil,and the latter representative drug is memantine.Since these drugs have undesirable side effects,it is necessary to find safer alternatives for AD treatment.Interestingly,dietary phytochemicals have the advantages of wide source,safety,...
Currently, only a few drugs, which function as acetylcholinesterase (AChE) inhibitors or N-methyl-D-aspartate (NMDA) receptor antagonists, are available to alleviate symptoms.Wu, XiaoaiCai, HuaweiPan, LiliCui, GangQin, FengLi, YunChunCai, Zhengxin...
Natural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The
To explore this possibility, it is important to evaluate whether the inhibitory effect of NMDA receptor antagonists would be confined to behaviors produced by drugs of abuse only, but not by natural reinforcers. According to the quantitative changes of NMDA receptor subunits, including NR1, NR2A,...