This detailed book provides a broad collection of methodologies for natural killer (NK) cell research. Beginning with an assortment of methods for the isolation of NK cells and NK cell differentiation, the volum
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK cells is their ability to recognize a wide range of cells in distress, particularly tumour cells and cells infected with viruses. They combine both direct effector functions against their cellular targets ...
Natural killer (NK) cells are innate lymphoid cells (ILCs) contributing to immune responses to microbes and tumors. Historically, their classification hinged on a limited array of surface protein markers. Here, we used single-cell RNA sequencing (scRNA-seq) and cellular indexing of transcriptomes ...
Can adaptive immune cells affect the innate immunoregulatory response? Natural killer (NK) cells are innate immune lymphocytes that mediate 2 major functions: recognition and lysis of tumor and virus-infected cells and production of immunoregulatory cytokines.8, 9The activation of an NK cell to kill...
2023,Methods in Cell Biology Felix BrunoKleine Borgmann, ...ClémentThomas Explore book 1Introduction Cytotoxic (CD8+)T lymphocytes(CTLs) and natural killer (NK) cells are two types of immuneeffector cellsof theimmune systemthat play a critical role in the surveillance of tumors through by ident...
such as natural killer (NK) cells, which exhibit significant cytotoxic activity against cancer cells and possess a safer immune profile, can be used as alternative approaches for immunotherapy of patients with R/R NHL. Moreover, it is also feasible to equip NK cells with a CAR structure [10...
Crosslinking of molecules involved in the recognition of target cells elicits natural killer (NK) cell cytotoxicity, inducing either release of preformed cytotoxic mediators via granule exocytosis, or (enhanced) expression of ligands for target cell membrane-associated molecules that transduce apoptotic sig...
NOD/SCID mice, derived from a backcross between SCID mice and non-obese diabetic mice, exhibit low levels of natural killer (NK) cells and a deficiency in complement C5. These traits contribute to higher survival rates of human cells and grafts [18]. To date, NOD/SCID mice have been ...
Chimeric antigen receptor-natural killer (CAR-NK) cell immunotherapy: A bibliometric analysis from 2004 to 2023 Wangshu Li, Jiuxiang Feng, Jianan Peng, Xu Zhang, Aziz Ur Rehman Aziz & Daqing Wang Article: 2415187 | Received 20 Aug 2024, Accepted 08 Oct 2024, Published online: 16 Oct...
Natural killer (NK) cells, a unique component of the innate immune system, are inherent killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells and good tolerance of healthy cells, NK cells have been successfully employed in adoptive cell therapy to treat ...