Multi-cellular cluster formation of natural killer (NK) cells occurs duringin vivopriming and potentiates their activation to IL-2. However, the precise mechanism underlying this synergy within NK cell clusters remains unclear. We employed lymphocyte-laden microwell technologies to modulate contact-...
L. Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9, 495–502 (2008). Article CAS PubMed PubMed Central Google Scholar Myers, J. A. & Miller, J. S. Exploring the NK cell platform for cancer immunotherapy. Nat. Rev. Clin. Oncol. 18, 85–100 (...
NK 细胞可以通过刺激“B 淋巴细胞”产生破坏特定抗原的抗体来增强对持续威胁的免疫反应。[76] 不幸的是,NK 细胞功能随着年龄的增长而下降会使老年人特别容易受到病毒感染,尤其是 冬季流感高峰期。但采用独特配方的酶改性米糠(EMRB) 开发出...
NK细胞在人体的功能 研究表明 年龄超过100岁的老年人也可以有效抵抗感染 因为其NK细胞系统功能完好 可以有效杀灭靶细胞, 而NK细胞受损的老年人易于感染流感、结核等疾病。 因此,NK细胞活性降低是疾病的前兆, 保持NK细胞的活性有助于延长寿命。 NK细胞在维持人体...
自然杀伤细胞,也称为NK 细胞或大颗粒淋巴细胞( LGL ),是一种对先天免疫系统至关重要的细胞毒性 淋巴细胞。它们属于快速扩增的已知先天淋巴细胞(ILC)家族,占人类所有循环淋巴细胞的 5-20%。 NK 细胞的作用类似于脊椎动物适应性免疫反应中的细胞毒性 T 细胞。NK 细胞基于来自几种激活和抑制受体的信号,对病毒感染细...
Natural Killer (NK) cells, a subset of innate lymphocytes that lack antigen-specificity, have a high cytolytic activity and by releasing cytotoxic granules are able to eliminate infected cells.See More Whether you're starting from whole blood, leukopaks, or PBMCs, explore our complete portfolio ...
L. Up on the tightrope: natural killer cell activation and inhibition. Nat. Immunol. 9, 495–502 (2008). Article CAS PubMed PubMed Central Google Scholar Myers, J. A. & Miller, J. S. Exploring the NK cell platform for cancer immunotherapy. Nat. Rev. Clin. Oncol. 18, 85–100 (...
Natural Killer (NK) cells perform immunological surveillance as one of the body’s first responders to infections and cancer.
Natural killer (NK) cell activity of first trimester human decidua. Cell Immunol. 1989 Jun; 121 (1):166–173.Manaseki S,Searle R F.Natural killer(NK) cell activity of first trimester human decidua. Cellular Immunology . 1989Manaseki S, Searle RF. Natural killer (NK) cell activity of ...
自然杀伤细胞(Natural killer cell,NK细胞 ),是除 T细胞、B细胞之外的第三大类淋巴细胞,不仅与抗肿瘤、抗病毒感染和免疫调节有关,甚至参与超敏反应和自身免疫性疾病的发生。 图1 NK细胞与其他免疫细胞 NK细胞来源于骨髓造血干细胞,属于先天免疫系统的核心细胞,约占血液中所有免疫细胞数量的15%;主要分布于外周血、...