代谢重编程已成为AML的标志性特征。由于LSCs对氨基酸，特别是氮和碳供体的需求旺盛，因此阻断其外源氨基酸摄取成为了一种有效的治疗策略，与venetoclax和阿扎胞苷联合治疗时，能够选择性地根除这些细胞。值得注意的是，近期研究揭示了丝氨酸在AML中的关键作用，特别是在FLT3-ITD阳性的AML亚型中。丝氨酸，作为一种条件性必需...
代谢重编程已成为AML的标志性特征。由于LSCs对氨基酸的高需求，尤其是氮和碳供体的主要来源——氨基酸，其在白血病发生中发挥着不可或缺的作用。研究显示，联合使用venetoclax和阿扎胞苷治疗时，通过阻断外源氨基酸的摄取可以有效地根除LSCs。值得注意的是，丝氨酸在AML中的依赖性日益受到关注，特别是在FLT3基因内部串联重复...
RNA modification has emerged as an important epigenetic mechanism that controls abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of RNA N4-acetylcytidine (ac4C) modification in AML remain elusive. Here, we report that ac4C and its catalytic enzyme NAT10 drive leu...
We observed that the RNA ac4C levels were significantly decreased uponNat10knockdown or KO in mouse HSPCs (Fig.1f,kand Extended Data Fig.1g,j,k), implying the potential involvement of ac4C in the oncogenic function ofNat10in AML. In addition to RNA, NAT10 and its yeast homologue Kre33 h...
PrognosisN-acetyltransferase 10 (NAT10) is considered as an oncogene in many tumors. This study investigated the NAT10 expression in Chinese acute myeloid leukemia (AML) patients and evaluated the predictive significance of NAT10 with a single-center retrospective study.The Oncomine was used to ...
急性髓系白血病(Acute myeloid leukemia,AML)是一种以造血干/祖细胞为起源的恶性克隆性血液系统疾病,是成人急性白血病中常见的类型,且生存期较短。尽管化疗可以杀死大部分的恶性细胞达到缓解目的,但仍有很大一部分患者复发。研究发现,患者骨髓...
In addition, the expression of NAT10 also was detected after AML12 hepatocytes cells were treated with 150 mol/L palmitic acid (PA). The ac4C mRNA modification was performed by dot blotting. Oil red O staining and the mRNA expression ofSrebf1,AcacaandFasnwere used to assess lipogenesis in ...