vaccine deliveryThe 'Nanopatch' (NP) comprises arrays of densely packed projections with a defined geometry and distribution designed to physically target vaccines directly to thousands of epidermal and dermal antigen presenting cells (APCs). These miniaturized arrays are two orders of magnitude smaller ...
D. It directs the vaccine to immune system through the skin. 相关知识点: 试题来源: 解析 [答案]D [.解析]细节理解题。根据as it is applied in dry form, into the skin and then targets a type of immune cell, the Langerhans cell, which lies just a hair's width from the surface of ...
This 2D nanopatch demonstrates robust adhesion to nasal mucosa and significantly enhances immunoglobulin A secretions, suggesting its potential for enhancing nasal vaccine delivery. The promise of a polyphenol-enabled adhesive 2D nanopatch signifies a pivotal shift from conventional spherical nanoparticles, ...
Potent response of QS- 21 as a vaccine adjuvant in the skin when delivered with the Nanopatch, resulted in adjuvant dose sparing. Sci Rep 2016;6:29368. https://doi.org/ 10.1038/srep29368.Ng, H.I.; Fernando, G.J.P.; Depelsenaire, A.C.I.; Kendall, M.A.F. Potent response of ...
We found, after vaccinating mice, that anti-influenza IgG antibody and haemagglutinin inhibition assay titre response induced by the Nanopatch (with delivered dose of 6.5 ng of vaccine and 1.4 μg of Quil-A) were equivalent to that of the conventional intramuscular injection using needle ...
VaccineA promising new delivery technology, the microarray patch (MAPs) consists of an array of small solid-coated or dissolvable needles, up to one mm in length, that administers a dry formulation of a vaccine or pharmaceutical. This study is not a real-life evaluation study but determines ...
Needle-free Nanopatch technology developed at The University of Queensland has been used to successfully deliver an inactivated poliovirus vaccine.
the Nanopatch, which has thousands of projections on the skin side, injects the vaccine just under the skin, where Kendall notes, there are more immune cells. This means, he added, that less vaccine is needed to accomplish the same goal which in turn means each dose would cost far less....