Vaccines that target conserved epitopes of influenza viruses would in principle offer broad cross-protection against influenza A viruses. In our study, we investigated the specific immune responses and protective efficacy of protein nanoparticles based on fusion proteins of flagellin carrier linked to ...
Herein we describe the formulation of nanoparticle based vaccines based on human Sp17 (hSp17) sequence derived peptides, and map the immuno-dominant T cell and antibody epitopes induced using such formulations. The primary T and B cell immuno-dominant region within Sp17 was found to be the ...
"The results are very encouraging", says the study's senior author, Jonathan Lovell, Ph.D., associate professor of biomedical engineering at the University at Buffalo. "Typically, flu vaccines contain either deactivated microbes that cause influenza, or they are based on weakened forms of the di...
“Typically, flu vaccines contain either deactivated microbes that cause influenza, or they are based on weakened forms of the disease. The vaccine we’re developing is a recombinant protein nanoparticle vaccine that stimulates a strong immune response,” Lovell says. The circle-shaped objects in th...
Influenza vaccines that confer broad and durable protection against diverse viral strains would have a major effect on global health, as they would lessen the need for annual vaccine reformulation and immunization1. Here we show that computationally designed, two-component nanoparticle immunogens2 induce...
systems were also used to express the VLPs of PV based on the P1 and 3CD genes [86,87]. The results of the immunogenicity experiment of plant-expressed VLPs showed that the levels of nAbs induced were similar to those induced by inactivated vaccines, and the challenged animals were protected...
The relative conservation of the influenza hemagglutinin (HA) stem compared to that of the immunodominant HA head makes the HA stem an attractive target for broadly protective influenza vaccines. Here we report the first-in-human, dose-escalation, open-l
Intranasal delivery of nanoparticle-based vaccines Most pathogens gain access to the human body and i Istvan,Toth,Mariusz,... - 《Therapeutic Delivery》 被引量: 5发表: 2017年 Multimerization of Ebola GPΔmucin on protein nanoparticle vaccines has minimal effect on elicitation of neutralizing antibo...
Take less time to generate large amounts because it is different from a majority of seasonal flu vaccines and is produced in embryonated chicken eggs The results are very encouraging. Typically, flu vaccines contain either deactivated microbes that cause influenza, or they are based on weakened ...
The present invention relates to nanoparticle vaccines comprised of a carrier, particularly polymerized lipids, having multiple copies of an antigen or combinations of different antigens displayed on the carrier. Such antigen-displaying nanoparticles may also display a targeting molecule on its surface in...