69and therefore the VHH-NJB2 nanobody detected tumors in both human and murine cancer models. Of note, the radiolabeled nanobody detectedpancreatic intraepithelial neoplasias(PanINs) in KPC mice. PanINs are precursor lesions that progress topancreatic ductal adenocarcinoma; at present, there is no ...
Product NameAnti-Human GSN(VHH 9) nanobody CAS MF MW0 EINECS MOL FileMol FileAnti-Human GSN(VHH 9) nanobody SupplierSend Inquriy MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer VersionChemical Book
Nanobodies, also known as VHH or single-domain antibodies, are unique antibody fragments derived solely from heavy chains. They offer advantages of small molecules and conventional antibodies, making them promising therapeutics. The paratope is the specific region on an antibody that binds to an ant...
Sortagging of liposomes with a murine CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells. Eur. J. Pharm. Biopharm. 134, 190–198 (2019). Article PubMed Google Scholar Mesquita, B. S. et al. The impact of nanobody density on the targeting ...
Sortagging of liposomes with a murine CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells. Eur. J. Pharm. Biopharm. 134, 190–198 (2019). Article PubMed Google Scholar Mesquita, B. S. et al. The impact of nanobody density on the targeting ...
The production and purification of Nb6E (previously named VHH05) has been described previously27. Briefly, BL21(DE3) E. coli were transfected via heat shock with plasmids encoding nanobodies of interest and grown in a medium (Terrific Broth) containing kanamycin (50 μg/mL). Transformed ...
These single domain antibodies are derived from the VHH domain of cameloid antibodies and contain three complementarity-determining regions (CDRs) specific to each Nb that mediate antigen binding. Because of their small size (∼13 kDa) and stable format, recombinant Nbs are often soluble and ...
Modeling the binding pose of an antibody is a prerequisite to structure-based affinity maturation and design. Without knowing a reliable binding pose, the subsequent structural simulation is largely futile. In this study, we have developed a method of ma
Nanobodies, or VHHs, refer to the antigen-binding domain of heavy-chain antibodies (HCAbs) from camelids. They have been widely used as research tools for protein purification and structure determination due to their small size, high specificity, and hig
serum from the same alpaca undergoes affinity purification of VHH protein fragments, which are analyzed by LC-MS/MS. The resulting MS data is compared with the sequence database generated from DNA sequencing reads to determine the corresponding VHH sequence [168]. This approach eliminates the need...