Annual Review of Biochemistry . First published online as a Review in Advance on March 13, 2013. . Nanobodies: Natural Single-Domain Antibodies . 原文链接:
Nanobodies, also called natural single-domain antibodies, comprise the antigen-binding region (i.e., VHH) derived from the variable domain of camelid heavy-chain antibodies (HCAbs) (Fig.4A). Different from conventional antibodies or fragments (i.e., fragment antigen-binding region (Fab) or si...
Nanobodies: natural single-domain antibodies. 来自 学术范 喜欢 1 阅读量: 958 作者: Serge Muyldermans 摘要: Sera of camelids contain both conventional heterotetrameric antibodies and unique functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric antibodies consists of ...
Nanobodies, also called natural single-domain antibodies, comprise the antigen-binding region (i.e., VHH) derived from the variable domain of camelid heavy-chain antibodies (HCAbs) (Fig.4A). Different from conventional antibodies or fragments (i.e., fragment antigen-binding region (Fab) or si...
Single-domain antibodies or nanobodies are a class of next-generation antibodies that have specific features: small size (in nanoscale), high penetration in various tissues, high stability in hard situations and ease production process in microbial systems. In fact single-domain antibodies are the ...
Nanobodies are also termed single domain antibodies, VHH antibodies, or camelid antibodies. This article will introduce nanobody information, including the difference between nanobodies and antibodies, nanobody structure, and nanobody advantages. Sino Bi
mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants. Preprint at https://doi.org/10.1101/2021.01.25.427948 (2021). Muyldermans, S. Nanobodies: natural single-domain antibodies. Annu. Rev. Biochem. 82, 775–797 (2013). Article CAS PubMed ...
预计下一代疗法中将开发Nb及其商业化。 参考资料 Annual Review of Biochemistry . First published online as a Review in Advance on March 13, 2013. . Nanobodies: Natural Single-Domain Antibodies . 原文链接:https://doi.org/10.1146/annurev-biochem-063011-092449...
Nanobodies: Natural single-domain antibodies. Annu. Rev. Biochem. 82, 775–797. https://doi.org/10.1146/annurev-biochem-063011-092449 (2013). Article CAS PubMed Google Scholar Hamers-Casterman, C. et al. Naturally occurring antibodies devoid of light chains. Nature 363, 446–448. https:...
VHH可溶性极高,不易聚集,能耐高温、强酸、强碱等致变性条件,适合于原核表达和各种真核表达系统,广泛用于开发治疗性抗体药物、诊断试剂、亲和纯化基质和科学研究等领域。