Background: Opioid-induced constipation (OIC) is common in critically ill patients; it leads to complications that can increase hospital stay and, rarely, bowel perforation. Opioid antagonists are considered a logical approach to treat OIC; however, the agent of choice has yet to be determined. ...
Opioids are an effective treatment for moderate-to-severe pain. However, they are associated with a number of gastrointestinal side effects, most commonly constipation. Laxatives do not target the underlying mechanism of opioid-induced constipation (OIC), so many patients do not have their symptoms ...
New formulation of sustained release naloxone can reverse opioid induced constipation without compromising the desired opioid effects. Pain Med. 2015;16:1540–... S Mark,J Stephen,L Oliver,... - 《Pain Medicine》 被引量: 4发表: 0年 Buprenorphine and naloxone combinations: the effects of three...
Introduction: Common opioids adverse effects include opioidinduced bowel dysfunction (OIBD), which comprises opioidinduced constipation, dry mouth, nausea, vomiting, gastric stasis, bloating, and abdominal pain. Traditional laxatives which are often prescribed for the prevention and treatment of OIBD poss...
Naloxoneis a reversal agent for theopioid analgesics. The primary indication is in the treatment of opioid-inducedrespiratory depression, chest wall rigidity, or overlydeep sedation. The drug has a peak effect in 5 to 15minutes, with a duration of action of 45minutes.Naloxoneshould be used with...
Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain. Curr Med Res Opin. 2008;24(12):3503–3512. 16. Vondrackova D, Leyendecker P, Meissner W, et al. Analgesic efficacy and safety of ...
of severe pain in adults that can only be effectively controlled using opioids, including cancer pain and non-cancer pain. Mimeixin contains naloxone, an opioid receptor antagonist, which reduces opioid-induced constipation (OIC) by blocking the binding of oxycodone to opioid receptors in the gut....
Opioid-induced constipation (OIC) is associated with negative impact of opioid analgesics on opioid receptors located in the gut wall. Until recently, OIC ... W Leppert - 《Advances in Therapy》 被引量: 87发表: 2010年 The influence of opioids on matrix metalloproteinase-2 and -9 secretion an...
Oxycodone/Naloxone prolonged- release: a review of its use in the management of chronic pain while counteracting opioid-induced constipation. ... CB Burness,GM Keating - 《Drugs》 被引量: 45发表: 2014年 Breast milk oxycodone concentrations in mothers given oxycodone for post‐Caesarean delivery ...
hospitalisation disability congenital anomaly requires intervention to prevent permanent impairment or damage A 57-year-old woman receiving bupropion [amfebutamone] and duloxetine developed a dyskinetic variant of neuroleptic malignant syndrome after receiving naloxone for reversal of presumptive opioid overdose...