Transiently antigen-primed B cells return to naive-like state in absence of T-cell help. Nat. Commun. 8:15072. doi:10.1038/ncomms15072.Turner JS., Marthi M., Benet ZL, and Grigorova I. (2017). Transiently antigen-primed B cells return to naive-like state in absence of T-cell help...
The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early
et al. Experience-driven development: effector/memory-like alphaE+Foxp3+ regulatory T cells originate from both naive T cells and naturally occurring naive... E Schmitt,JHC Siewert,U Lauer,... - 《Journal of Immunology》 被引量: 15发表: 2008年 The immune cell infiltrate populating meningiomas...
The efficiency of naive T-cell infiltration into tumours was lower than that into LN; however, it was consistent with the lower PNAd expression on tumour vasculature (Fig. 2c). Disruption of chemokine signalling in transferred naive OT-I cells by pertussis toxin pretreatment prevented their ...
Also, because DNA methylation is a highly heritable mark, we reasoned that even if tdhTSCs have acquired an overall hTSC-like phenotype, they might still bear traces of their cell of origin or their period as naive hESCs. We performed whole-genome bisulfite sequencing of CT1, CT3, WIBR3 ...
Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients. Eur J Immunol 2001; 31:2256-65.Tanchot C, Le Campion A, Lâeaument S, Dautigny N, Lucas B. Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients...
Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients. Eur J Immunol 2001; 31:2256-65.Tanchot C, Le Campion A, Leaument S, Dautigny N, Lucas B. na¨ive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients...
CD8 T cells play a crucial role in immune responses to virus infections and tumors. Nave CD8 T lymphocytes after TCR stimulation undergo differentiation into CTLs and memory cells, which are essential sources of IFN-纬. We investigated IFN-纬 production by CD8 T cell subsets found in non...
In this study, we show that freshly isolated peripheral blood T cells are heterogeneous in their expression levels of LAIR-1. We have found that naive T cells express the highest levels of LAIR-1, even more than memory cells. The cross-linking of LAIR-1 inhibits T cell receptor (TCR) ...
To explore the role of p66Shc in stem cell self-renewal and differentiation, we created a p66Shc knockout murine embryonic stem cell (mESC) line. Deletion of p66Shc enhanced basal ERK activity, but surprisingly, instead of inducing mESC differentiation, loss of p66Shc enhanced the expression...