与幼稚T细胞不同,记忆T细胞可以被B细胞、巨噬细胞等众多细胞激活,而不仅仅是树突状细胞,而且对于TCR以及共刺激分子的刺激更敏感。按照记忆细胞分布位置和功能的不同,可以分为中心记忆T细胞(Tcm,central memory),效应记忆T细胞(Tem,effector memory),驻留记忆细胞(Trm, resident memory)和记忆干细胞(Tscm,stem cell mem...
Memory T lymphocytes proliferate in vivo in the absence of antigen maintaining a pool of central memory T cells (TCM) and effector memory T cells (TEM) with distinct effector function and homing capacity. We compared human CD4+naive T, TCM, and TEMcells for their capacity to proliferate in ...
Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu. Rev. Immunol. 22, 745–763 (2004). 38. Saha, B., Mondal, A. C., Basu, S. & Dasgupta, P. S. Circulating dopamine level, in lung carcinoma patients, inhibits proliferation and cytotoxicity ...
Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission Background Dendritic cells (DC) have been proposed to facilitate sexual transmission of HIV-1 by capture of the virus in the mucosa and subsequent transmis... F Groot,...
Klebanoff, C.A. et al. Central memory self/tumor-reactive CD8+T cells confer superior antitumor immunity compared with effector memory T cells.Proc. Natl. Acad. Sci. USA102, 9571–9576 (2005). ArticleCASGoogle Scholar Berger, C. et al. Adoptive transfer of effector CD8+T cells derived fr...
Recent works on the heterogeneity of the human CD4+ and CD8+ T cells have individualized 4 subsets: namely, naive (CCR7+CD45RA+), central memory (TCM, CCR7+CD45RA), effector memory (TEM, CCR7CD45RA), and CD45RA+ effector memory cells (TEMRA, CCR7CD45RA+). To our knowledge, the ...
2D). A significant proportion of T cells displayed a Tn cell phenotype (CD62L+ CD45RO–), and phenotypic transition from naive to central memory T cells (Tcm; CD62L+CD45RO+) and effector memory T cells (Tem; CD62L–CD45RO+) was observed in PB and spleen of transplanted mice (...
In addition, a novel subpopulation of CD80+CD27+ resting memory B cells in human peripheral blood with a low threshold of activation and ability to deliver vigorous memory effector responses further highlighted the diversity that exists within the memory B cell compartment 37. Previously, Liu ...
For initial experiments, PBMCs were sorted into naive (TN, CD62L+CD45RA+), central memory (TCM, CD62L+CD45RA–), effector memory (TEM, CD62L–CD45RA–), and terminal differentiated T cells (TT, CD62L–CD45RA+). Second, PBMCs were fractionated into more generalized subsets by sor...
, central memory (CM), and effector memory (EM) T cells. Naive T cells were cultured for 6 days with IFNγ-pretreated SEB-loaded KCs and analyzed for surface expression of the indicated chemokine receptors. a Representative immunohistochemical staining of a skin lesion from a psoriasis patient ...