机译:T-Lymphocytes;Transcription Factors;binding;Antigens;CD8;T淋巴细胞;转录因子;抗原;CD8; 相似文献 外文文献 中文文献 专利 1. Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-...
CD8+T cells recognize peptides of 8–11 amino acids in length, presented by MHC class I molecules on the cell surface [9], [10]. Because the peptides that bind to MHC class I molecules are primarily derived from proteins synthesized within the cell [11], [12] and because all ...
The percentage of CD3+, CD3+CD4+, and CD3+CD8+ cells among lymphocytes allowed us to obtain the absolute number of total T lymphocytes, CD4 T cells, and CD8 T cells, respectively. Thereafter during analysis, an electronic gate placed on CD3+ cells and the correlated expression of CD4 or ...
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2, 415–422 (2001). Article CAS Google Scholar Kaech, S.M., Wherry, E.J. & Ahmed, R. Effector and memory T-cell differentiation: implications for vaccine ...
CD8+ T cells are present at a higher frequency following a primary response, and these memory cells exhibit qualitative differences from naive cells. The importance of these differences vs increased precursor frequency in making a memory response more rapid and efficient has been unclear. Adoptive tr...
cytotoxic CD8+ T cells predominated as effectors in tumor tissues, tumor infiltrating FOXP3+ CD4+ regulatory T cells exhibited highly immunosuppressive characteristics. 有一说一,作者图表还是蛮清晰的,而且有新意,可以让人比较容易确实各个单细胞亚群的生物学合理性,也可以看到极端的比例差异: ...
什么是Naïve T cell T细胞是免疫系统适应性免疫分支中的一个重要部分,每个T细胞都有特殊的T受体(TCR),通过重排等生物学活动成熟。TCR与抗原呈递细胞(APC)上的抗原肽结合,发生联级反应,引发炎症。T细胞也可以识别癌症。所有的T 细胞都是从骨髓中的干细胞发育而来。这些未分化的细胞同骨髓迁移到了胸腺,在那里获得...
Naive CD8 T cells proliferated extensively, migrated to tissues, developed effector function, and were capable of making a recall response. These features are very different from the abortive activation of CD8 T cells that occurred in response to the same antigen presented by APC from other ...
A well-known consequence of TCR stimulation in proliferating T cells is cell death by apoptosis. We have previously shown that the extent of tyrosine phosphorylation of TCRζ, CD3γ, and CD3ϵ subunits in proliferating CD4−CD8+ T cells after TCR stimulation was decreased when compared to si...