更重要的是,WT B 细胞最终变得独立于自身反应性 B 细胞,能够在自身反应性 B 细胞缺失的情况下维持 GC 反应。 2024年3月22日,美国哈佛医学院Michael C. Carroll在Science Immunology上发表题为“Invasion of spontaneous germinal centers by naive Bcellsis rapid and persistent”的文章。本研究证实自身反应性GC的...
Naïve B cells present in human tonsil and spleen are morphologically small cells that express intermediate levels of IgM and CD21, high levels of IgD and CD23, and low to negligible levels of activation antigens such as CD80, CD86, and CD95. ...
什么是Naïve B cell 与T细胞类似,B细胞也是从干细胞分化而来,通过接触独特的抗原分化后激活。B细胞表面受体BCR与外来抗原结合后发挥下游生物学功能。通常来说,B细胞发育的最后阶段在脾脏中,在那里发育成初始B细胞。这些不被激活的初始B细胞随着血液进入到刺激淋巴器官(SLO)。初始的B细胞更容易捕获病原体,因为SLO的...
P Reichardt,B Dornbach,S Rong,S Beissert,M Gunzer 摘要: Naive B cells are ineffective antigen-presenting cells and are considered unable to activate naive T cells. However, antigen-specific contact of these cells leads to stable cell pairs that remain associated over hours in vivo. The ...
The perspective that naive B-cell recognition of antigen in the absence of T-cell help causes cell death or anergy is supported by in vivo studies of B cells that are continuously exposed to self-antigens. However, intravital imaging suggests that early
Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature. 489:160- 164. http://dx.doi.org/10.1038/nature11311Zikherman J, Parameswaran R, Weiss A. Endogenous antigen tunes the respon- siveness of naive B cells but not T cells. Nature...
Ighb strains had larger numbers of PE-specific naive B cells and generated smaller germinal center responses and larger numbers of IgM memory cells than the Igha strain. The properties of PE-specific B cells in Ighb mice correlated with usage of a single VH that afforded high-affinity PE ...
We show that the transient BLyS treatment used in this study substantially affected naive B cell populations; in particular, it resulted in more B cells surviving counter-selection at the transitional stages. We also observed more mature naive B cells, especially marginal zone B cells, in BLyS-...
Neonatal B cells with the naive (sIgD + ) phenotype are able to generate IgG- and IgA-producing cells as well as IgM production in the presence of memory CD4 + T cells expressing L-selectin (CD62L) in pokeweed mitogen-stimulated cultures. We used this system to examine comparatively the ...
(DN2)) B cells, expansion of CD19+antibody-secreting cells (ASCs) and depression of mutation frequencies in the ASC repertoire, these responses are highly similar to those we had identified previously in patients with active severe systemic lupus erythematosus (SLE)13,20. In these patients, ...