NHE)分泌进入小管液中，与小管液中的Na⁺进行交换。这种Na⁺-H⁺交换是一个继发性主动转运，所需...
—The Na+/H+ exchangers (NHEs) are membrane-bound transporters that catalyze the electro-neutral movement of extracellular Na+ for intracellular H+. NHE genes play a critical role in pH homeostasis and cellular volume regulation and can be ...
H Yu,BI Freedman,SS Rich,DW Bowden 摘要: The Na+/H+ exchangers (NHEs) are membrane-bound transporters that catalyze the electro-neutral movement of extracellular Na+ for intracellular H+. NHE genes play a critical role in pH homeostasis and cellular volume regulation and can be considered ...
Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines Na+/H+ exchangers (NHEs) are transporters that exchange sodium and proton ions across the plasma membrane at the expense of their chemical gradient. In hig... J Noel,D Roux,J Pouys...
激活NHE1.3N唧的功能3.1调节细胞内pH值和影响细胞离子转运:但在缺血,缺氧的情况下或在肿瘤细胞.细胞内大量H嘴留,导致多种信号通路上调激活NHE系统.将胞内H泵出细胞外,使细胞内酸中毒得以纠正.NHE是以等分子比例进行细胞内外Na+一H交换,而Na梯度由Na*-K*一ATP酶提供能量维持.在细胞缺血,缺氧,酸中毒等情况下,...
Na(+)/H(+) exchangers (NHE1 来自 ResearchGate 喜欢 0 阅读量: 59 作者: ME Cavet 摘要: NHE1, NHE2, and NHE3 are well-characterized cloned members of the mammalian Na(+)/H(+) exchanger (NHE) gene family. Given the specialized function and regulation of NHE1, NHE2, and NHE3, we ...
In mammalian cells changes in intracellular pH (pHi), which are predominantly controlled by activity of plasma membrane ion exchangers, regulate a diverse range of normal and pathological cellular processes. How changes in pHi affect distinct cellular pr
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. Eukaryotic Na(+)/H(+) exchangers are transmembrane proteins that are vital for cellular homeostasis and play key roles in pathological conditions such as c... M Landau,K Herz,E Padan,... - 《Journal...
The absence of the PDZ domain protein Na+/H+ exchange regulatory factor 1 (NHERF1) in mice, or its mutation in humans, causes osteomalacia believed to reflect renal phosphate wasting. We show that NHERF1 is expressed by mineralizing osteoblasts and organizes Na+/H+ exchangers (NHEs) and ...
Na+/H+ exchanger 1 (NHE1), an important regulator of intracellular pH (pHi) and extracellular pH (pHe), plays a crucial role in various physiological and pathological processes. However, the role of NHE1 in depression has not yet been reported. This study was designed to investigate the ro...