Na⁺⁻H⁺交换，简单的可以理解为 Na⁺⁻H⁺交换体（即NHE），但从原理来看也应该包含ENaC...
Na+/H+ exchangers (NHEs) are known to be important regulators of pH in multiple intracellular compartments of eukaryotic cells. Sperm function is especially dependent on changes in pH and thus it has been postulated that NHEs play important roles in regulating the intracellular pH of these cells...
Six mammalian Na+/H+ exchangers, NHE1, NHE2, NHE3, NHE4, NHE5 (Attaphitaya et al. 1999; Szabo et al. 2000), and NHE6, have been described (Tse et al. 1994; Orlowski 1999; Counillon and Pouysségur 2000).This is a preview of subscription content, log in via an institution ...
In metazoan cells pHihomeostasis is maintained by a number of H+translocating mechanisms, primarily localized at the plasma membrane. In mammalian fibroblasts, a predominant regulator of pHiis the Na-H exchanger, NHE1. NHE1 is an H+extruder, catalyzing an electroneutral exchange of extracellular N...
The myocardial Na+/H+ exchange (NHE) represents a major mechanism for pH regulation during normal physiological processes but especially during ischaemia a
Na+/H+ exchanger 1 (NHE1), an important regulator of intracellular pH (pHi) and extracellular pH (pHe), plays a crucial role in various physiological and pathological processes. However, the role of NHE1 in depression has not yet been reported. This study was designed to investigate the ro...
Na+/H+ exchangers (NHE), also called antiporters, are vital transmembrane transporters involved in multiple cellular functions including the regulation of intracellular pH, the control of cell volume and transepithelial ion transport. These transporters are highly regulated by a remarkably wide variety ...
The Na+/H+ exchangers (NHE)1 are a family of integral membrane proteins that translocate Na+ in exchange for H+ across the cell surface and mitochondrial membranes. Na+/H+ exchange is electroneutral and is therefore driven by the combined chemical gradients of Na+and H+. NHE plays an imp...
Keywords Na+/H+ exchanger NHE1 Protein kinase C isotype Calcium Epidermal growth factor NIH3T3 1. Introduction Na+/H+ exchangers (NHE) are important regulators of cytoplasmic pH. Up to now, six isoforms (NHE1–NHE6) have been identified [1], [2]. The NHE1 isoform [3] is ubiquitously...
To assess the roles of gastric acid and the brush-border acidic microclimate in aiding intestinal iron transport, we have examined iron homeostasis and intestinal iron handling in mouse models lacking the 伪-subunit of the gastric H/K-ATPase (gHKA) or the brush-border Na/Hexchangers NHE3 and...