Na/H exchangers NHE1 and NHE3, of rat intestine. J Clin Invest 93: 106-113, 1994.Bookstein, C , DePaoli, A.M., Xie, Y., Niu, P., Musch, M.W., Rao, M.C., and Chang, E.B. 1994a. ...
题外话,这个特性与组织细胞的缺血-再灌注损伤的钙超载也有关,也就是NHE和NCX的耦联。缺氧胞内酸中毒时,NHE把H排出,Na+泵入,而胞内Na+浓度高了会刺激NCX排Na,吸收Ca2+。 信号通路机制如下图 摘自Na+/H+ Exchangers in Renal Regulation of Acid-Base Balance 另外,闰细胞上的H⁺-K⁺交换体和H⁺泵...
其中,Na+/H+ 交换体家族第三个亚型 (Na+/H+ ex- changerisoform3,NHE3)高度表达于肠道和肾近端小管中发挥中性 NaCl的吸收作用,当细菌,病毒和毒素等病原 感染肠道后,会引起肠上皮细胞上相应的 NHE3活性受到抑制和 Na+ 转运障碍,从而使得肠道内的水和电解质潴留,营养物质吸收停滞并导致腹泻的发生.近年来,...
0笔记 摘要原文 Na+/H+ exchangers (NHEs) conduct the electroneutral exchange of proton (H+) and sodium (Na+) ions across cellular membranes down their concentration gradients. To date, nine NHE family members have been cloned from mammals and share a common secondary structure. The ubiquitous ...
H Yu,BI Freedman,SS Rich,DW Bowden 摘要: The Na+/H+ exchangers (NHEs) are membrane-bound transporters that catalyze the electro-neutral movement of extracellular Na+ for intracellular H+. NHE genes play a critical role in pH homeostasis and cellular volume regulation and can be considered ...
Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines Na+/H+ exchangers (NHEs) are transporters that exchange sodium and proton ions across the plasma membrane at the expense of their chemical gradient. In hig... J Noel,D Roux,J Pouys...
激活NHE1.3N唧的功能3.1调节细胞内pH值和影响细胞离子转运:但在缺血,缺氧的情况下或在肿瘤细胞.细胞内大量H嘴留,导致多种信号通路上调激活NHE系统.将胞内H泵出细胞外,使细胞内酸中毒得以纠正.NHE是以等分子比例进行细胞内外Na+一H交换,而Na梯度由Na*-K*一ATP酶提供能量维持.在细胞缺血,缺氧,酸中毒等情况下,...
Na(+)/H(+) exchangers (NHE1 来自 ResearchGate 喜欢 0 阅读量: 54 作者: ME Cavet 摘要: NHE1, NHE2, and NHE3 are well-characterized cloned members of the mammalian Na(+)/H(+) exchanger (NHE) gene family. Given the specialized function and regulation of NHE1, NHE2, and NHE3, we ...
The Na+/H+ exchangers (NHE)1 are a family of integral membrane proteins that translocate Na+ in exchange for H+ across the cell surface and mitochondrial membranes. Na+/H+ exchange is electroneutral and is therefore driven by the combined chemical gradients of Na+and H+. NHE plays an imp...
Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications. Eukaryotic Na(+)/H(+) exchangers are transmembrane proteins that are vital for cellular homeostasis and play key roles in pathological conditions such as c... M Landau,K Herz,E Padan,... - 《Journal...