YTH N6甲基腺苷RNA结合蛋白(YTH N6-methyladenosine RNA binding protein,YTHDF)1可与mRNA终止密码子附近的m6A位点结合,从而促进RNA翻译。而YTHDF2通过募集一种叫作CCR4-NOT的腺苷酸酶复合物,来促进m6A修饰的转录产物的降解。YTHDF3能够与YTHDF1结合,共同作用...
N6‐methyladenosine (m6A) is the most abundant chemical modification of eukaryotic messenger RNA (mRNA) and is important for the regulation of mRNA stability, splicing, and translation. Using transcriptome sequencing, we discovered that methyltransferase‐like 3 (METTL3), a major RNA N6‐adenosine ...
N6-Methyladenosine (m6A) RNA modification is present in messenger RNAs (mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although mRNA m6A modifications have been extensively studied and shown to play critical roles in many cellular processes, the identity of m6A methyltransfe...
N6-甲基腺苷(N6-methyladenosine,m6A)甲基化:是指发生在RNA腺嘌呤N6位点上的甲基化修饰,是一种动态可逆的修饰模式,m6A修饰在转录后水平上调控RNA翻译、可变剪切、转运、定位和降解等,是真核生物mRNA中最丰富的表观遗传修饰,在调控各种细胞的分化、修复、侵袭和凋亡中起重要作用。 甲基转移酶样3(methyltransferase like...
N6-甲基腺嘌呤(N6-methyladenosine,m6A)是真核生物信使RNA(Messenger RNA,mRNA)上含量最多的化学修饰之一。m6A修饰是动态可逆的,可在时间和空间上被甲基转移酶和去甲基酶调控。哺乳动物体内m6A甲基转移酶复合物中有一部分成分已被解析,主要有METTL3 (Methyltransferase-like protein 3)、METTL14 (Methyltransferase-like...
N6-methyladenosine METTL3: Methyltransferase-like 3 METTL14: Methyltransferase-like 14 WTAP: Wilms’ tumour-associated protein lncRNAs: Long noncoding RNAs VIRMA(KIAA1429): Vir Like M6A methyltransferase associated ZC3H13: Zinc finger CCCH-type containing 13 ...
The N6‐methyladenosine (m6A) modification is the most common modification of messenger RNAs in eukaryotes and has crucial roles in multiple cancers, including in urological malignancies such as renal cell carcinoma, bladder cancer and prostate cancer. The m6A RNA modification is controlled by three ...
RNA甲基化修饰是一种重要的表观遗传学修饰方式,在不改变基因序列的情况下,导致基因的表达和功能的变化,其中最常见的是N6-甲基腺嘌呤(N6-methyladenosine,m6A)甲基化修饰。m6A 可以发生在真核生物细胞的各类RNA,介导目标RNA 的各项生物学过程,对其表达和功能进行调控。
N6-甲基腺嘌呤(N6-methyladenosine,m6A)是发生在RNA腺嘌呤(A)碱基第6位氮原子上的甲基化,主要由甲基转移酶(Writers)、去甲基化酶(Erasers)和相关结合蛋白(Readers)共同调控,参与RNA转录、剪接、加工、翻译和衰变等多种生物学过程[1-3]。肝脏是调控机体新陈代谢的主要器官,m6A甲基化参与肝脏疾病的发生、发展过程(...
Macrophage polarization is associated with the RNA epigenetic alteration N6-methyladenosine (m6A) RNA methylation. However, the specific function and underlying mechanisms of m6A methylation in the role of macrophage polarization in RA remain to be elucidated. The mRNA expression levels of m6A methylase...