N-Dealkylation of tertiary amines has been studied extensively by reaction with a variety of oxidizing agents. The oxidation of amines is dependent on the reaction conditions, the oxidizing agent and the structure of the amine. However, there is little correlation between reaction intermediates and ...
ChemInform Abstract: A Novel N-Dealkylation Reaction of N,N-Dialkylarylcarboxamides Promoted by Electron Transfer from Alkali Metalsalkylation, arylation, dealkylation, dearylation, C゛cylation, olefinationketones (benzene compounds)carboxylic amides (benzene compounds)...
The reaction was dependent on the incubation time, amount of enzyme, and concentration of aminopyrine and hydrogen peroxide. Under the experimental conditions employed, the specific activity for N-demethylation of aminopyrine was found to be 823 ± 93 nmoles per min/mg protein or 89 ± 10 ...
Another important N-dealkylation reaction in living systems is the repair of alkylated DNA, which eliminates the alkylation damage at nitrogen atoms in nucleobases in the DNA structure upon the exposure of living cells to 3alkylating agents. If the N-alkylated modifications in the DNA structure are...
DNA with branched internal side chains: synthesis of 5-tripropargylamine-dU and conjugation by an azide-alkyne double click reaction. Chembiochem 9, 2305–2316 (2008). Article CAS Google Scholar Alcantar, N. A., Aydil, E. S. & Israelachvili, J. N. Polyethylene glycol-coated ...
The reactions of halogenocyclotetraphosphazatetraenes N4P4X8, with nucleophiles have received little attention and only the reactions of the octachloride, N4P4Cl8, with amines have been investigated in any detail.1 Millington and Sowerby2 studied the reaction of N4P4Cl8 with dimethylamine and ...
The reaction of 4-substituted N,N-dimethylanilines 1a–d with acetic anhydride 5 proceeded efficiently in the presence of a catalytic amount of cobalt(II) ... Satoru,Murata,Kaoru,... - 《Journal of the Chemical Society》 被引量: 20发表: 1992年 加载更多站...
N-Methyl-6-amino-3-azabicyclohexane derivatives 8, 9 and 25 can be demethylated by reacting the corresponding N-oxides with acetic anhydride in a Polonovsky reaction and subsequent cleavage of the resulting acetamides by hydrochloric acid. Other demethylating reagents such as cyanogen bromide, ...
Karaman et al, " A Novel N-Dealkylation Reaction of N, N-Dialkylarylcarboxamies Promoted by Electron Transfer From Alkali Metals ", Tetrahedron Lett., 31, 941-944, 1990.R. Karaman, et al., " A Novel N-Dealkylation Reaction of N,N-Dialkylarylcarboxamides Promoted by Electron Transfer ...
ChemInform Abstract: Unusual N-Dealkylation in the Reaction of 5-Allyl-4,4-dimethoxy-2,3,5- trichloro-2-cyclopentenone with Secondary Aminesamination, deaminationcyclopentane derivativesChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about ...