NLRP3/Caspase-1 pathwaysurface plasmon resonance assayNeuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases.However,there is a lack of effective drugs to treat neuroinflammation.N-acetyldopamine dimer(NADD)is a natural compound from the traditional ...
Aspongamide F (1), a novel N-acetyldopamine (NADA) dimer possessing a 6/6/6 ring system, and (+/-)-aspongamides G (2) and H (3), rare NADA derivatives with fragmented benzene rings, were isolated from Aspongopus chinensis. (+/-)-Cicadamides C (4) and D (5), the first 1...
N-acetyldopamine dimer BMetabolic profilesCharacterizationUPLC-QTOF-MS/MSCicadae Periostracum (CP), the cast-off shell of Cryptotympana atrata, is specified in Chinese Pharmacopoeia for relieving fever and eliminating ulcer. N-acetyldopamine oligomers are the major characteristic bioactive components ...
In the structure suggested for the dimer both phenolic groups of one molecule of N-acetyldopamine are connected to the 尾-position of another. It is shown that a considerable part of the amino and phenolic groups in hardened cuticle is not free to react with blocking agents. It is suggested...
The product of nonenzymatic oxidation was found to be not the expected o-benzoquinone derivative, but a benzodioxan-type dimer. Although mushroom tyrosinase also catalyzed this reaction (Sugumaran et al.: Journal of Biological Chemistry 262:10546-10549, 1987), cuticular phenoloxidase(s) from Sarco...
Previously, we also isolated some acetyldopamine polymers from PC extract, among which acetyldopamine dimer A (NADA) was present in high content. Molecular docking and molecular dynamic simulations demonstrated that NADA could form stable complexes with 5-HT1A, BDNF, and D2R proteins, respectively. ...