Neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases.However,there is a lack of effective drugs to treat neuroinflammation.N-acetyldopamine dimer(NADD)is a natural compound from the traditional Chinese medicine Isaria cicada.In our previous study,...
N-acetyldopamine derivativesCOX-2renal protectionNATURAL-PRODUCTSAspongamide F (1), a novel N-acetyldopamine (NADA) dimer possessing a 6/6/6 ring system, and (+/-)-aspongamides G (2) and H (3), rare NADA derivatives with fragmented benzene rings, were isolated from Aspongopus chinensis...
N-acetyldopamine oligomersN-acetyldopamine dimer BMetabolic profilesCharacterizationUPLC-QTOF-MS/MSCicadae Periostracum (CP), the cast-off shell of Cryptotympana atrata, is specified in Chinese Pharmacopoeia for relieving fever and eliminating ulcer. N-acetyldopamine oligomers are the major ...
In the structure suggested for the dimer both phenolic groups of one molecule of N-acetyldopamine are connected to the 尾-position of another. It is shown that a considerable part of the amino and phenolic groups in hardened cuticle is not free to react with blocking agents. It is suggested...
Sugumaran M, Hennigan B, Semensi V, Dali H. On the nature of nonenzymatic and enzymatic oxidation of the putative sclerotizing precursor, 1,2-dehydro- N- acetyldopamine. Arch Insect Biochem Physiol. 1988; 8 :89–100.M. Sugumaran, B. Hennigan, V. Semensi, H. Dali. On the nature ...
The UPLC-ESI-QTOF-MS analysis determined that PC extract mainly contained N-acetyldopamine components. Previously, we also isolated some acetyldopamine polymers from PC extract, among which acetyldopamine dimer A (NADA) was present in high content. Molecular docking and molecular dynamic simulations ...