体内研究在5 mg/kg体重的药物当量剂量下,含有溶酶体可降解侧链的所有N-(2-羟丙基)甲基丙烯酰胺共聚物药物共轭物显示出显著的体内抗利什曼原虫活性(>99%抑制率)[1]。 参考文献 [1].Nan A, et al. N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers for targeted delivery of 8-aminoquinoline antileishmania...
N-(2- Hydroxypropyl)methacrylamide (HPMA) Copolymer-Linked Nitroxides: Potential Magnetic Resonance Contrast Agents. In Macromolecular Bioscience 2003, 647-652.Huang, Y.; Nan, A.; Rosen, G. M.; Winalski, C. S.; Schneider, E.; Tsai, P.; Ghandehari, H., N-(2-Hydroxypropyl)...
英文名称:N-(2-Hydroxypropyl)methacrylamide 英文别名:2-Propenamide,N-(2-hydroxypropyl)-2-methyl-;N-(2-Hydroxypropyl)-2-methylprop-2-enamide;N-(2-hydroxypropyl)methacrylamide;1-methacryloylamino-2-hydroxypropane;N-(2-hydroxypropyl)methacrylamide);HPMA;N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide CAS...
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers bearing galactosamine residues accumulate in the liver after intravenous administration to rats (Duncan, R., Kopec̆ek, J., Rejmanová, P. and Lloyd, J.B. (1983) Biochim. Biophys. Acta 755, 518–521). In this study HPMA copolymers beari...
多聚N-(2-羟丙基)甲基丙烯酰胺-抗肿瘤药物偶合物的研究进展 万方数据
N-(2-hydroxypropyl) methacrylamide (HPMA) copolyme r -Mitoxantrone conjugates was successf- ully synthesized and characterized a s an anti-cancer drug for solid tumors. The biodistribution and pharmacokinetic s of the conjugates were examined in mice bearing Ehrlich solid tumor. The biodi stributio...
To investigate the relative importance of active and passive targeting strategies, the synthesis, characterization, in vitro uptake, and in vivo biodistribution of specific sulfapyridine HPMA (HPMA: N-(2-hydroxypropyl methacrylamide)) copolymer (sulfapyridine: SPD) conjugates, nonspecific HPMA copolymer ...
N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers have been described in the literature as soluble drug carriers. The fate of such polymers in biological systems is conveniently examined using radioactively labeled polymers. We describe the preparation of a new copolymer of HPMA (I) with N-[2-...
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers bearing galactosamine residues accumulate in the liver after intravenous administration to rats (Duncan, R., Kopec̆ek, J., Rejmanová, P. and Lloyd, J.B. (1983) Biochim. Biophys. Acta 755, 518–521). In this study HPMA copolymers beari...
The homopolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) and copolymers of HPMA differing in oligopeptide side chains (-Gly-Gly-OH; -Acap-Phe-OH; -Acap-Leu-HMDA and -Gly-Phe-Tyr-OH) or in their content (1%, 3,5% and 8,4% mole of-Gly-Gly-OH side chains) were investigated with...