www.nature.com/scientificreports OPEN Determination of the pKa of the N-terminal amino group of ubiquitin by NMR received: 14 November 2016 accepted: 26 January 2017 Published: 02 March 2017 Alain Oregioni1,*, Benjamin Stieglitz2,†,*, Geoffrey Kelly1, Katrin Rittinger2 & Tom...
Kung KK-Y, Wong K-F, Leung K-C, Wong M-K (2013) N- Terminal αa-amino group modification of peptides by an oxime formation-exchange reaction sequence. Chem Commun (Camb) 49: 6888-6890.Kung, K. K.-Y.; Wong, K.-F.; Leung, K.-C.; Wong, M.-K. N- terminal α-amino ...
摘要: A site-specific and efficient method for N-terminal modification of peptides using oxone for selective oxidation of N-terminal α-amino groups of peptides to oximes followed by transoximation with O-substituted hydroxylamines has been developed....
Previously, SUMO conjugation has only been known to occur on ε-amino groups of internal lysine residues of the target proteins. Our finding provides the first evidence that SUMOylation at the N-terminal α-amino group of a protein, rather than the internal lysine(s), is essential and ...
Creative Peptides has advancedpeptide synthesisabilities and provides more than 40 types of N-terminal modifications to meet your needs in different research fields. What is the N-terminal of a peptide? The N-terminal of a peptide is the end of the amino acid chain where the amino group (-...
The amino-teminal laminin G-like domain of human sex hormone-binding globulin (SHBG), which contains the steroid-binding site and the dimerization domain, has been produced in Escherichia coli , purified to homogeneity and crystallized in complex with 5±-dihydrotestosterone (DHT) in two dif...
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Non-peptidyl compounds characterized generally as ethereal N-terminal aminodiol derivatives of amino acids are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein X is selected from oxygen atom and methylene; wherein R1...
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N-terminal acetylation (Nt-acetylation) is a widespread protein modification among eukaryotes and prokaryotes alike. By appending an acetyl group to the N-terminal amino group, the charge, hydrophobicity, and size of the N-terminus is altered in an irrev