M. ‘Gramicidin S’: over-all chemical characteristics and amino-acid composition. Biochem. J. 39, 363–367 (1945). Article CAS PubMed PubMed Central Google Scholar Gordon, A. H., Martin, A. J. P. & Synge, R. L. M. Proceedings of the Biochemical Society. Biochem. J. 40, ...
Here we reveal that I(1,3,4,6)P4, I(1,3,4,5,6)P5, and IP6promote membrane permeabilization by MLKL through directly binding the N-terminal executioner domain (NED) and dissociating its auto-inhibitory region. We show that IP6and inositol pentakisphosphate 2-kinase (IPPK) are required...
(1) What are the effects of 5 formulations and doses of nitroglycerin on 2 markers of bone formation (serum bone specific alkaline phosphatase (BALP) and procollagen type I N-terminal propeptide (P1NP)) and 2 markers of bone resorption (serum C-telopeptide (CTX) and urine N-telopeptide (...
The significance of such nonsynonymous SNPs to disease susceptibility is well established, but how silent or synonymous SNPs that do not change the amino acid sequence can lead to disease remains a puzzle. Two recent studies of silent SNPs within the human population (Nackley et al., 2006; ...
(a) Haploid parental strains and the four spores/strains of a representative tetrad derived from their cross was analyzed for growth on rich medium (YPD, top), tubular ( þ /normal) or netted (N) mitochondrial morphology, sensitivity (S) to acetic acid-induced cell death, resistance (R)...
A 15-amino acid V2 -derived peptide is sufficient to mediate binding to α4β7. It includes the canonical LDV/I α4β7 binding site, a cryptic epitope that lies 7–9 amino acids amino terminal to the LDV/I, and residues K169 and I181. These two residues...
Biochemical and genetic analysis of the embryonic to adult beta-like globin gene switch in chickens has led to the hypothesis that competition between the promoters of the cis-linked epsilon- and beta-globin genes for interaction with a shared enhancer mediates the developmental changes in expression...
Ground seeds were wetted with 1 N NaOH and incubated for 1 h in 1000 ml of chloro- form. The chloroform–seed mixture was then soni- cated for 20 min and then filtered through cheesecloth to remove the seed debris. The remain- ing chloroform solution was then acid hydrolyzed for 1 h ...
11. A system for the solid phase synthesis of multiple peptides each formed by repeated synthetic cycles of synthetic steps, said system comprising: a first set of syringes each holding a solid support; a second set of syringes each holding a desired amino acid, said first set of syringes...
3. The composition of claim 2 wherein the solid non-polymeric gellant is selected from the group consisting of 12-hydroxystearic acid, esters of 12-hydroxystearic acid, amides of 12-hydroxystearic acid, C20 to C40 fatty acids, n-acyl amino acid amides and n-acyl amino acid esters of gl...