The results will help provide personalized dietary recommendations for macronutrients in terms of postprandial blood glucose responses. The proposed n-of-1 trial methods could help in optimizing individual health and advancing health care. This trial was registered with clinicaltrials.gov (NCT04125602)....
1 人赞同了该文章 Milasen and Its Successors Paving the Way for Accessible Patient-Customized Oligonucleotide Therapies. Regulatory Insights from FDA Guidances on Patient-Customized Oligonucleotide Therapies for SDLT represent a significant effort to expedite the commencement of clinical trials for these inn...
N-of-1 or single subjectclinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient ...
N-of-1 or single subject clinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient...
N-of-1 or single subject clinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient...
n-of-1 Trialsnear-universal human tendencyclinical trial mechanismTreatment Effects Measurementindividual shrink effectsfalse-negative resultsgenuine treatment effectmultiplicity-general problemRandom-effects analysistreatment effects distributionbetween-patient, within-patient and treatment-by-patient interaction...
N-of-1 or single subjectclinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient...
FullText A series of n-of-1 trials among statin-intolerant participants found no difference in frequency and intensity of muscle symptoms while they were taking the medication compared with a placebo, astudyinThe BMJreported. A smaller n-of-1 trial published in theNew England Jo...
The n-of-1 Randomized Controlled Trial: Clinical Usefulness: Our Three-Year Experience To review the feasibility and effectiveness of n-of-1 randomized controlled trials (n-of-1 trials) in clinical practice. Individual trials were double-blin... GH Guyatt,JL Keller,R Jaeschke,... - 《...
以期国内研究人员实施 N-of-1 试验方案时,能够使用正确的样本量 估计方法,从而提高我国 N-of-1 试验的研究质量。 【关键词】 单病例随机对照试验;N-of-1 试验;样本量;固定模型;随机模型 Sample size estimation for single case randomized controlled trial (N-of-1 trial) CHEN Xinlin Basic Medical College...