1990年,该团队对1986年至1989年间73个有不同疾病的患者所实施的N-of-1 trial(所研究的疾病包括:慢性、失眠、慢性阻塞性肺疾病、类风湿关节炎、骨关节炎和过敏性哮喘)进行了全面详细的总结和客观的统计分析,进一步验证并详细描述N-of-1 trial方法的适用性、可行性以及潜在优势。与此同时,在《内科学年鉴》(Annals...
N-of-1 or single subjectclinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient ...
N-of-1 or single subject clinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient...
N-of-1 or single subjectclinical trialsconsider an individual patient as the sole unit of observation in a study investigating the efficacy or adverse effects of different interventions. The ultimate goal of an N-of-1 trial is to determine theoptimal or best interventionfor an individual patient ...
The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Personalized medicine. 2011; 8 (2):161–173.Lillie EO, Patay B, Diamant J, et al. . The n-of-1 clinical trial: the ultimate strategy for individualizing medicine? Personalized Med 2011;...
n-of-1 Trialsnear-universal human tendencyclinical trial mechanismTreatment Effects Measurementindividual shrink effectsfalse-negative resultsgenuine treatment effectmultiplicity-general problemRandom-effects analysistreatment effects distributionbetween-patient, within-patient and treatment-by-patient interaction...
The n-of-1 clinical trials consist of the only tool for the delivery of evidence-based, personalized obesity treatment (lifestyle and pharmacotherapy), reducing non-responders, while tailoring the best intervention to each patient, through “trial and error”. Their application is expected to impro...
【Key words 】 Single case randomized controlled trial; N-of-1 trial; Sample size; Fixed model; Random model 单病例随机对照试验(single case randomized 而国内研究者对 N-of-1 试验样本量的估算上仍存 controlled trial )简称 N-of-1 试验,是一种基于单个 在困扰,很多研究者并不知道正确的样本量...
A person-centric clinical trial is inclusive of both the investigator and the person and as such represents point-of-use data generated at the practice level and encompasses both health and disease. Raising the clinical encounter to a research encounter and providing an infrastructure to support a...
A series of n-of-1 trials among statin-intolerant participants found no difference in frequency and intensity of muscle symptoms while they were taking the medication compared with a placebo, a study in The BMJ reported. A smaller n-of-1 trial published in the New England Jour...