Control of T Cell-mediated Autoimmunity by Metabolite Flux to N-Glycan Biosynthesis Autoimmunity is a complex trait disease where the environment influences susceptibility to disease by unclear mechanisms. T cell receptor clustering and si... A Grigorian,SU Lee,W Tian,... - 《Journal of ...
N-Glycan biosynthesis 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 N-聚糖的生物合成 翻译结果2复制译文编辑译文朗读译文返回顶部...
The antennary hypothesis has inspired a great deal of interest in the structure, function, and biosynthesis of the antennae of branched complex N-glycans. Gal occupies the terminal non-reducing position on N-glycan antennae, and is an uncharged alternative to sialic acid. Although there is ...
The top three relevant pathways were glycan biosynthesis and metabolism, metabolism of cofactors and vitamins, and lipid metabolism. Overall, sex may be an important factor for urinary N⁃glycoproteome differ⁃ ences among normal individuals and should be considered in clinical applications. This ...
Figure1. Types of glycan chains 大量研究表明,细胞恶变过程中某些糖链加工酶基因表达的上调或下调,将 改变细胞所合成的糖蛋白糖链结构。目前糖链结构与疾病关系的研究已引起广泛 的重视,特别是生物膜中的糖蛋白,因为这些蛋白质发挥其生物学功能与糖基化 密切相关[12]。这些糖蛋白上的糖链结构在生物和物理特征上均...
This enzyme is capable of trimming high mannose oligosaccharides to Man5GlcNAc2 duringN-glycan biosynthesis. Human α1,2-mannosidase IC requires calcium for activity and is inhibited by 1-deoxymannojirimycin and kifunensine; thus, it possesses the characteristic properties of class I α1,2-...
Mechanisms of O-Mannosyl Glycan Biosynthesis in Mammals We previously reported that a defect in O-mannosyl glycan is the primary cause of a group of congenital muscular dystrophies. Based on our pioneering findi... H Manya - 《Trends in Glycoscience & Glycotechnology》 被引量: 0发表: 2019年...
We have previously isolated glycopeptides derived from yeast invertase that acted as highly potent elicitors in suspension-cultured tomato cells, inducing ethylene biosynthesis and phenylalanine ammon... 详情 Peracylation of nucleosides with methionine: foundation for a method to detect carcinogen adducts...
本研究内容丰富、结果详实, 初步揭示了pro-Met的N-糖基化修饰在肿瘤细胞HGF/c-Met信号通路中对c-Met功能的影响, 从而对c-Met下游PI3K/Akt和 MEK/ERK两条信号通路影响, 导致肿瘤细胞增殖、分化和迁移等生物学行为的改变. 研究对于阐明HGF/c-Met信号通路在肿瘤发生、发展中确切机制及其分子靶向治疗方面具有重要的...
在转录后水平,microRNA的调节可影响甲状腺癌分化基因表达,而PI3K信号通路的激活、磷脂酰肌醇糖基锚生物合成U类(phosphatidylinositol glycan anchor biosynthesis class U, PIGU)表达下降等则会抑制NIS糖基化,影响其正常细胞膜定位[6]。 综...