N-degron和C-degron分别被对应的E3连接酶识别,致使底物蛋白降解的通路就被称为N端降解通路(N-degron pathways)和C端降解通路(C-degron pathways)。 宓文义教授和董城教授两个团队的研究扩展了N端降解通路的分支,他们首先通过多肽阵列芯片技术对ZE...
N-degrons are generated by various cellular processes including proteolytic cleavages, hierarchical enzymatic steps, and post-translational modifications. In eukaryotes, four N-degron pathways have been reported to date: the Arg/N-degron pathway (2, 7), the Ac/N-degron pathway (8, 9), the ...
The currently known functions of the Ac/N-degron pathway are implicated in the control of protein quality; subunit stoichiometry (in complexes) (16); blood pressure (via G-protein signaling) (17); lipid droplet level (18); circadian rhythm (19); and plant immunity, development, and stress ...
Internal Medicine, College of Medicine, Seoul National University, Seoul 110-799,KoreaAbstractThe N-end rule pathway is a proteolytic system in which N-terminal residues of short-livedproteins are recognized by recognition components (N-recognins) as essential components ofdegrons, called N-degrons...
近期,基础医学院宓文义教授和董城教授两个课题组合作于Nature Communications上发表题为CRL2ZER1/ZYG11B recognizes small N-terminal residues for degradation的文章,报道了一种新型的N端降解通路Non-ac/N-degron pathway。在这个通路中,E3连接酶ZE...