This chapter describes the activity, specificity and structural chemistry of N-Acetylmuramoyl- l -alanine amidase. N-Acetylmuramoyl- l -alanine amidases are peptidoglycan hydrolases with the specificity to cleave the amide bond between the lactyl group of the muramic acid and the α-amino group of...
Lipogranulomatosis caused by deficiency of acid ceramide degrading enzyme (EC 3.5.1.23, N-acylsphingosine amidohydrolase, 395aa), a storage disease. Farmer’s lung Type III hypersensitivity response to Micropolyspora faeni, a thermophilic bacterium found in mouldy hay. Enzyme of the endoplasmic reticu...
acyl/aroyl thioureas; urease inhibitors; synthesis; enzyme inhibitory kinetics; molecular docking Graphical Abstract Highlights: * Novel amantadine-thiourea molecular hybrids (3a–j) synthesized and assayed for in vitro urease inhibition. * Compound 3j with 7-carbon alkyl chain showed excellent activity...